Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 234419..235071 Replicon plasmid pSS37A-Re-1
Accession NZ_AP027143
Organism Methylocystis iwaonis strain SS37A-Re

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG84_RS18880 Protein ID WP_281932192.1
Coordinates 234667..235071 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMG84_RS18875 Protein ID WP_281932190.1
Coordinates 234419..234670 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG84_RS18845 (SS37A_37550) 230235..230900 + 666 WP_281932180.1 DUF938 domain-containing protein -
QMG84_RS18850 (SS37A_37560) 230897..231586 + 690 WP_281932182.1 spermidine synthase -
QMG84_RS18855 232243..232329 - 87 Protein_210 IS5/IS1182 family transposase -
QMG84_RS18860 (SS37A_37570) 232359..233003 - 645 WP_281932184.1 DJ-1/PfpI family protein -
QMG84_RS18865 232996..233145 + 150 WP_281932186.1 hypothetical protein -
QMG84_RS18870 (SS37A_37580) 233263..234261 + 999 WP_281932188.1 DJ-1/PfpI family protein -
QMG84_RS18875 (SS37A_37590) 234419..234670 + 252 WP_281932190.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QMG84_RS18880 (SS37A_37600) 234667..235071 + 405 WP_281932192.1 type II toxin-antitoxin system VapC family toxin Toxin
QMG84_RS18885 (SS37A_37610) 235304..235642 + 339 WP_281932502.1 cupin domain-containing protein -
QMG84_RS18890 235673..236206 + 534 WP_281932194.1 hypothetical protein -
QMG84_RS18895 (SS37A_37620) 236466..236918 + 453 WP_281932196.1 DUF6041 domain-containing protein -
QMG84_RS18900 (SS37A_37630) 237003..238649 + 1647 WP_281932198.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..320171 320171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-127)

Antitoxin

Antitoxin VapB-like

(4-80)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14736.82 Da        Isoelectric Point: 4.8836

>T43036 WP_281932192.1 NZ_AP027143:234667-235071 [Methylocystis iwaonis]
MMIDASAFLAILLEEPDGPEMAQRIAAAKAPYTSPLAVYETCARLMSARQIAANDAQDMLRELLDEAAVRVVPITEGMTS
VALGAFEKYGRSRHPAAFNFGDCFAYACARAYRARLLFKGNDFSQTDINDSVRY

Download         Length: 405 bp

>T43036 NZ_AP027143:234667-235071 [Methylocystis iwaonis]
ATGATGATCGACGCATCCGCGTTTCTCGCGATCCTTCTGGAAGAGCCGGATGGCCCGGAGATGGCGCAGCGTATCGCTGC
GGCGAAGGCGCCATATACGTCCCCTCTCGCGGTTTATGAGACCTGCGCGCGCCTGATGAGCGCGCGCCAGATCGCCGCCA
ATGACGCGCAGGACATGCTGCGCGAATTGCTGGACGAGGCCGCCGTGCGCGTCGTTCCTATCACTGAAGGCATGACAAGC
GTCGCGCTCGGCGCGTTCGAGAAATACGGGCGAAGCCGCCATCCCGCCGCTTTCAATTTCGGGGATTGCTTCGCTTACGC
CTGTGCTCGCGCCTACCGCGCGCGCCTCTTGTTCAAAGGCAATGATTTTTCGCAGACCGACATCAATGATTCCGTGAGAT
ATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.01 Da        Isoelectric Point: 9.7504

>AT43036 WP_281932190.1 NZ_AP027143:234419-234670 [Methylocystis iwaonis]
VAYSIKDPETDELIRKLAKAKRKPIVEAIKEACANELARERAKIPLWERLQPLRARVASHPARPEQTHASHKGFFDDMWS
DEK

Download         Length: 252 bp

>AT43036 NZ_AP027143:234419-234670 [Methylocystis iwaonis]
GTGGCGTATAGCATCAAAGACCCCGAAACCGACGAGCTCATCCGCAAGCTCGCAAAGGCGAAGCGCAAGCCCATCGTCGA
GGCGATCAAGGAAGCCTGCGCGAATGAGCTCGCGCGCGAGCGGGCGAAAATCCCTTTGTGGGAACGACTGCAGCCGCTTC
GCGCGCGCGTCGCGTCGCACCCCGCCCGGCCCGAACAAACGCACGCGAGCCACAAGGGTTTTTTCGATGATATGTGGAGC
GACGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References