Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3306013..3306593 Replicon chromosome
Accession NZ_AP027142
Organism Methylocystis iwaonis strain SS37A-Re

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QMG84_RS15720 Protein ID WP_202071465.1
Coordinates 3306234..3306593 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QMG84_RS15715 Protein ID WP_281929041.1
Coordinates 3306013..3306237 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG84_RS15690 (SS37A_31090) 3301341..3301847 - 507 WP_281929033.1 CBS domain-containing protein -
QMG84_RS15695 (SS37A_31100) 3302033..3302668 - 636 WP_281929034.1 TetR/AcrR family transcriptional regulator -
QMG84_RS15700 (SS37A_31110) 3302773..3303771 + 999 WP_281929036.1 aldo/keto reductase -
QMG84_RS15705 (SS37A_31120) 3303814..3304719 - 906 WP_281929038.1 LysR family transcriptional regulator -
QMG84_RS15710 (SS37A_31130) 3304863..3305900 + 1038 WP_281929039.1 aldo/keto reductase -
QMG84_RS15715 (SS37A_31140) 3306013..3306237 + 225 WP_281929041.1 antitoxin MazE family protein Antitoxin
QMG84_RS15720 (SS37A_31150) 3306234..3306593 + 360 WP_202071465.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QMG84_RS15735 (SS37A_31160) 3307082..3308026 - 945 WP_281932043.1 3-hydroxyisobutyrate dehydrogenase -
QMG84_RS15740 (SS37A_31170) 3307972..3309468 - 1497 WP_281929045.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
QMG84_RS15745 (SS37A_31180) 3309495..3310502 - 1008 WP_281929047.1 fumarylacetoacetate hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(12-73)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13074.87 Da        Isoelectric Point: 9.1165

>T43034 WP_202071465.1 NZ_AP027142:3306234-3306593 [Methylocystis iwaonis]
MRRGDIWTVSGGKHYAGKPRPVVIVQDDSFDATDSITICAFTTDPTEAPLFRLLVEPNERNGLNSSSRLMVDKITTVPKS
KAGERIGRLDDEDVVRLNQAVMVFLGLAASSRTGRKGER

Download         Length: 360 bp

>T43034 NZ_AP027142:3306234-3306593 [Methylocystis iwaonis]
ATGAGGCGGGGAGACATCTGGACCGTTTCCGGCGGCAAGCACTACGCAGGCAAGCCTCGCCCCGTCGTCATCGTGCAGGA
CGACAGCTTCGATGCGACGGATTCGATCACGATCTGCGCCTTCACCACGGACCCGACCGAAGCGCCTCTGTTCCGGCTTC
TGGTGGAGCCAAACGAGCGCAACGGGCTAAATTCCTCCTCTCGGCTGATGGTGGACAAGATTACCACCGTCCCGAAATCC
AAGGCCGGAGAGCGGATCGGCCGGCTGGACGACGAGGACGTGGTCCGGCTCAACCAGGCTGTGATGGTGTTCCTCGGCTT
GGCGGCGTCGTCGAGAACGGGCCGGAAAGGGGAACGATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8362.40 Da        Isoelectric Point: 8.9533

>AT43034 WP_281929041.1 NZ_AP027142:3306013-3306237 [Methylocystis iwaonis]
MVQARGTKPIKVKVREHRDRLRAQGLRPIQIWVPDVRASSFRSEAHRQSLAVAASAHAAEDQAFIDAVSDWDEE

Download         Length: 225 bp

>AT43034 NZ_AP027142:3306013-3306237 [Methylocystis iwaonis]
ATGGTGCAGGCGAGAGGCACGAAGCCCATCAAGGTGAAGGTGCGGGAGCACCGAGACCGGCTGCGCGCCCAAGGCCTGCG
GCCGATCCAGATTTGGGTGCCGGATGTGCGGGCGTCGTCCTTCCGATCTGAGGCGCACCGGCAATCTCTGGCCGTGGCGG
CGAGCGCCCATGCTGCCGAAGATCAGGCGTTCATCGACGCCGTGTCCGACTGGGACGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References