Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1942440..1943055 Replicon chromosome
Accession NZ_AP027142
Organism Methylocystis iwaonis strain SS37A-Re

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG84_RS09315 Protein ID WP_281927444.1
Coordinates 1942440..1942844 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMG84_RS09320 Protein ID WP_281927445.1
Coordinates 1942828..1943055 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG84_RS09310 (SS37A_18380) 1937711..1942408 + 4698 WP_281927442.1 glutamate synthase large subunit -
QMG84_RS09315 (SS37A_18390) 1942440..1942844 - 405 WP_281927444.1 PIN domain-containing protein Toxin
QMG84_RS09320 (SS37A_18400) 1942828..1943055 - 228 WP_281927445.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QMG84_RS09325 (SS37A_18410) 1943277..1944695 + 1419 WP_281927447.1 glutamate synthase subunit beta -
QMG84_RS09330 (SS37A_18420) 1944703..1944912 + 210 WP_202071595.1 hypothetical protein -
QMG84_RS09335 (SS37A_18430) 1945247..1945909 - 663 WP_281927449.1 L,D-transpeptidase -
QMG84_RS09340 (SS37A_18440) 1946055..1947473 - 1419 WP_281927450.1 SGNH family hydrolase -
QMG84_RS09345 (SS37A_18450) 1947472..1947933 + 462 WP_281927451.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-118)

Antitoxin

SpoVT-AbrB domain

(5-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14744.83 Da        Isoelectric Point: 6.2215

>T43033 WP_281927444.1 NZ_AP027142:c1942844-1942440 [Methylocystis iwaonis]
MTTRNRSFFDTNVLLYAVATSGAKADISEELIALGGVVSIQVLNEFAAVSRRKHNASWQNVKASLESFRATLDIVPLTLE
THQTGVALAERYNFAIYDAMIVAAAKLAGCRTLYTEDLHNGQILDQLKIENPFV

Download         Length: 405 bp

>T43033 NZ_AP027142:c1942844-1942440 [Methylocystis iwaonis]
ATGACGACGAGGAATAGAAGCTTCTTCGATACGAACGTCCTTCTATACGCGGTCGCGACCTCCGGCGCCAAAGCGGATAT
CTCCGAAGAGTTGATTGCGCTCGGCGGCGTCGTCAGCATTCAGGTTCTGAACGAGTTCGCCGCCGTTTCTCGGCGCAAAC
ACAATGCTTCGTGGCAGAATGTGAAGGCGAGTTTAGAATCGTTTCGAGCGACGCTCGACATCGTTCCCCTTACCCTTGAA
ACGCACCAGACCGGCGTCGCTCTTGCCGAGCGCTACAATTTTGCAATCTATGACGCCATGATCGTGGCGGCAGCTAAATT
AGCGGGCTGCCGGACGCTCTATACGGAGGACCTGCATAATGGGCAGATCCTCGATCAACTAAAAATCGAGAACCCGTTTG
TCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8551.68 Da        Isoelectric Point: 4.8779

>AT43033 WP_281927445.1 NZ_AP027142:c1943055-1942828 [Methylocystis iwaonis]
MRVSRWGNSLAVRLPADLVREKGLKEGDEVSITVESMIDEKARARAEAIAALRNLRGMIPADYRFKREDAYDDEE

Download         Length: 228 bp

>AT43033 NZ_AP027142:c1943055-1942828 [Methylocystis iwaonis]
ATGCGCGTCTCACGATGGGGAAATAGCCTTGCCGTGCGCCTGCCCGCCGACCTCGTGCGGGAGAAGGGCCTGAAGGAAGG
CGACGAGGTATCGATCACGGTCGAGTCGATGATCGACGAAAAAGCCCGCGCTCGCGCCGAGGCGATCGCTGCTCTCCGGA
ACCTTCGCGGGATGATCCCGGCCGATTACAGGTTCAAACGCGAAGACGCATATGACGACGAGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References