Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 269332..269979 Replicon chromosome
Accession NZ_AP027142
Organism Methylocystis iwaonis strain SS37A-Re

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMG84_RS01290 Protein ID WP_281929905.1
Coordinates 269332..269733 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMG84_RS01295 Protein ID WP_281929907.1
Coordinates 269737..269979 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG84_RS01265 (SS37A_02530) 264907..265512 - 606 WP_281929897.1 sensor histidine kinase -
QMG84_RS01270 (SS37A_02540) 265636..266637 - 1002 WP_281929899.1 LPS export ABC transporter ATP-binding protein -
QMG84_RS01275 (SS37A_02550) 266782..267387 - 606 WP_281929901.1 3-isopropylmalate dehydratase small subunit -
QMG84_RS01280 (SS37A_02560) 267559..268194 + 636 WP_281929902.1 cyclic nucleotide-binding domain-containing protein -
QMG84_RS01285 (SS37A_02570) 268465..269085 - 621 WP_281929904.1 L,D-transpeptidase -
QMG84_RS01290 (SS37A_02580) 269332..269733 - 402 WP_281929905.1 type II toxin-antitoxin system VapC family toxin Toxin
QMG84_RS01295 (SS37A_02590) 269737..269979 - 243 WP_281929907.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QMG84_RS01300 (SS37A_02600) 270040..271212 - 1173 WP_281929909.1 phosphoserine transaminase -
QMG84_RS01305 (SS37A_02610) 271300..271764 - 465 WP_281929910.1 hypothetical protein -
QMG84_RS01310 (SS37A_02620) 271919..272215 + 297 WP_281929911.1 DUF6156 family protein -
QMG84_RS01315 (SS37A_02630) 272223..273248 - 1026 WP_281929914.1 hypothetical protein -
QMG84_RS01320 (SS37A_02640) 274065..274376 - 312 WP_281929915.1 BolA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14740.96 Da        Isoelectric Point: 6.8725

>T43031 WP_281929905.1 NZ_AP027142:c269733-269332 [Methylocystis iwaonis]
MRYLLDTNAVIHLLKTADSALARRLRQHRPEDVCISAIVTHELYFGAFKSARVEANLARLQALLFEVLPFDLEDSIASGE
IRAKLRAEGTPIGPYDLLIAGQALARGLTLVSANVKEFRRVEGLTVEDWTHSG

Download         Length: 402 bp

>T43031 NZ_AP027142:c269733-269332 [Methylocystis iwaonis]
TTGCGCTACCTTCTGGACACCAACGCCGTCATCCACCTCCTGAAGACGGCGGACTCGGCGCTCGCGCGAAGGCTGCGCCA
GCACCGGCCGGAAGACGTTTGCATCTCGGCGATCGTCACCCACGAACTCTATTTCGGCGCCTTCAAAAGCGCTCGGGTCG
AGGCCAATCTCGCCCGGCTGCAAGCCTTGCTGTTCGAGGTGCTGCCCTTCGACCTGGAAGACTCTATCGCCTCGGGGGAG
ATTCGCGCGAAGTTGCGCGCGGAAGGGACGCCCATCGGCCCATATGATCTCCTCATCGCCGGGCAGGCGCTGGCGCGGGG
TCTCACGCTCGTTTCCGCGAATGTAAAAGAGTTCCGCCGCGTTGAAGGGCTGACGGTCGAAGACTGGACCCACTCGGGCT
AA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9413.64 Da        Isoelectric Point: 4.5271

>AT43031 WP_281929907.1 NZ_AP027142:c269979-269737 [Methylocystis iwaonis]
MDKAKLFWSGRSQAVRLPKDYRIEADEVRIRRRGDTIILEPIPKDWTWLDTLAGTLSEDFLEEGREQPPIQERPDLDSVF

Download         Length: 243 bp

>AT43031 NZ_AP027142:c269979-269737 [Methylocystis iwaonis]
ATGGACAAAGCGAAGCTATTCTGGTCCGGCCGTTCACAGGCGGTGCGGCTTCCGAAAGACTATCGCATTGAAGCGGATGA
GGTGCGAATCCGCCGGCGCGGCGACACGATCATTCTCGAGCCAATCCCGAAAGACTGGACTTGGCTCGACACGCTCGCGG
GAACGCTCTCCGAGGACTTTCTGGAAGAGGGCCGCGAGCAGCCGCCCATCCAAGAGCGTCCTGACCTCGACAGCGTATTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References