43015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1635810..1636504 Replicon chromosome
Accession NZ_AP027136
Organism Enterococcus faecalis strain JARB-HU0796

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QUD94_RS08030 Protein ID WP_033918698.1
Coordinates 1636160..1636504 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QUD94_RS08025 Protein ID WP_016627611.1
Coordinates 1635810..1636142 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD94_RS07975 (1630978) 1630978..1631757 - 780 WP_033918691.1 DnaD domain protein -
QUD94_RS07980 (1631772) 1631772..1632587 - 816 WP_033918692.1 PD-(D/E)XK nuclease-like domain-containing protein -
QUD94_RS07985 (1632550) 1632550..1633521 - 972 WP_033918693.1 RecT family recombinase -
QUD94_RS07990 (1633614) 1633614..1633970 - 357 WP_033918694.1 hypothetical protein -
QUD94_RS07995 (1633973) 1633973..1634197 - 225 WP_033918695.1 hypothetical protein -
QUD94_RS08000 (1634197) 1634197..1634517 - 321 WP_033918696.1 hypothetical protein -
QUD94_RS08005 (1634585) 1634585..1634773 - 189 WP_033918697.1 hypothetical protein -
QUD94_RS08010 (1634770) 1634770..1634991 - 222 WP_229294412.1 aspartate decarboxylase -
QUD94_RS08015 (1635007) 1635007..1635318 - 312 WP_016617789.1 hypothetical protein -
QUD94_RS08020 (1635330) 1635330..1635521 - 192 WP_010712202.1 hypothetical protein -
QUD94_RS08025 (1635810) 1635810..1636142 + 333 WP_016627611.1 helix-turn-helix transcriptional regulator Antitoxin
QUD94_RS08030 (1636160) 1636160..1636504 + 345 WP_033918698.1 ImmA/IrrE family metallo-endopeptidase Toxin
QUD94_RS08035 (1636538) 1636538..1637266 + 729 WP_033918699.1 potassium channel family protein -
QUD94_RS08040 (1637363) 1637363..1638511 + 1149 WP_033918700.1 site-specific integrase -
QUD94_RS08045 (1638539) 1638539..1638982 - 444 WP_129992406.1 competence type IV pilus minor pilin ComGD -
QUD94_RS08050 (1638979) 1638979..1639254 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
QUD94_RS08055 (1639254) 1639254..1640300 - 1047 WP_002369171.1 competence type IV pilus assembly protein ComGB -
QUD94_RS08060 (1640257) 1640257..1641225 - 969 WP_010710572.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13718.69 Da        Isoelectric Point: 6.1372

>T43015 WP_033918698.1 NZ_AP027136:1636160-1636504 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHEGQFNYSNVVTHYNLKMGQETYLK

Download         Length: 345 bp

>T43015 NZ_AP027136:1636160-1636504 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGAAGGTCAGTTTAATTATTCTAATGTGGTTACCCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12551.16 Da        Isoelectric Point: 5.2341

>AT43015 WP_016627611.1 NZ_AP027136:1635810-1636142 [Enterococcus faecalis]
MTVFEIIQMLAKKQGKSVKDVSRELGFGESTIYKWKKQSPKAEYIEKVAQYFNVSTDYLLGRTDNPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT43015 NZ_AP027136:1635810-1636142 [Enterococcus faecalis]
ATGACAGTATTTGAGATAATACAAATGCTTGCAAAAAAACAAGGAAAAAGTGTTAAAGATGTGTCAAGAGAACTTGGTTT
TGGAGAAAGCACTATTTACAAATGGAAGAAACAATCTCCAAAAGCTGAATACATCGAAAAGGTAGCCCAGTATTTTAATG
TTTCAACCGACTATTTATTAGGTAGAACGGATAATCCAAACCAAGCTGGCGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References