Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2139880..2140394 Replicon chromosome
Accession NZ_AP027135
Organism Staphylococcus aureus strain JP089

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QMM73_RS10660 Protein ID WP_000581792.1
Coordinates 2139880..2140089 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QMM73_RS10665 Protein ID WP_000138932.1
Coordinates 2140101..2140394 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM73_RS10640 (2135388) 2135388..2136746 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QMM73_RS10645 (2136761) 2136761..2137831 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
QMM73_RS10650 (2138149) 2138149..2139351 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QMM73_RS10655 (2139615) 2139615..2139752 - 138 WP_000828354.1 Lmo0850 family protein -
QMM73_RS10660 (2139880) 2139880..2140089 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QMM73_RS10665 (2140101) 2140101..2140394 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QMM73_RS10670 (2140560) 2140560..2142044 + 1485 WP_000571549.1 cardiolipin synthase -
QMM73_RS10675 (2142072) 2142072..2142719 + 648 WP_001187630.1 HD domain-containing protein -
QMM73_RS10680 (2143632) 2143632..2144504 - 873 WP_000725802.1 membrane protein insertase YidC -
QMM73_RS10685 (2144590) 2144590..2145231 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T43003 WP_000581792.1 NZ_AP027135:c2140089-2139880 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T43003 NZ_AP027135:c2140089-2139880 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT43003 WP_000138932.1 NZ_AP027135:c2140394-2140101 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT43003 NZ_AP027135:c2140394-2140101 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References