Detailed information of TA system TA042996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 871752..872229
• Replicon: chromosome
• Accession: NZ_AP027135
• Organism: Staphylococcus aureus strain JP089

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: QMM73_RS04270
• Protein ID: WP_061737428.1
• Coordinates: 871752..871940 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: QMM73_RS04275
• Protein ID: WP_001059690.1
• Coordinates: 871969..872229 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM73_RS04240 (867744)	867744..868265	+	522	WP_061838849.1	hypothetical protein	-
QMM73_RS04245 (868606)	868606..869292	+	687	WP_061838850.1	thermonuclease family protein	-
QMM73_RS04250 (869649)	869649..869849	+	201	WP_001059082.1	cold-shock protein	-
QMM73_RS04255 (870343)	870343..870561	-	219	WP_061838851.1	hypothetical protein	-
QMM73_RS04260 (870623)	870623..870907	-	285	WP_061838852.1	hypothetical protein	-
QMM73_RS04265 (870995)	870995..871564	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
QMM73_RS04270 (871752)	871752..871940	-	189	WP_061737428.1	hypothetical protein	Toxin
QMM73_RS04275 (871969)	871969..872229	-	261	WP_001059690.1	hypothetical protein	Antitoxin
QMM73_RS04280 (872570)	872570..872773	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
QMM73_RS04285 (872770)	872770..873006	-	237	WP_000368687.1	hypothetical protein	-
QMM73_RS04290 (873231)	873231..873812	+	582	WP_001140693.1	histidine phosphatase family protein	-
QMM73_RS04295 (873885)	873885..874502	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
QMM73_RS04300 (874657)	874657..875151	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
QMM73_RS04305 (875550)	875550..875972	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
QMM73_RS04310 (876120)	876120..876836	+	717	WP_000150018.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	clfA / vWbp	807378..882504	75126

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7170.87 Da
• Isoelectric Point: 9.9971

>T42996 WP_061737428.1 NZ_AP027135:c871940-871752 [Staphylococcus aureus]
MSLHFAILFWLALIFLVVATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T42996 NZ_AP027135:c871940-871752 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGTCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT42996 WP_001059690.1 NZ_AP027135:c872229-871969 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT42996 NZ_AP027135:c872229-871969 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VN56