Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2132071..2132585 Replicon chromosome
Accession NZ_AP027134
Organism Staphylococcus aureus strain JP008

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QMM94_RS10500 Protein ID WP_000581792.1
Coordinates 2132071..2132280 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QMM94_RS10505 Protein ID WP_000138932.1
Coordinates 2132292..2132585 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM94_RS10480 (2127579) 2127579..2128937 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QMM94_RS10485 (2128952) 2128952..2130022 - 1071 WP_000159632.1 D-alanine--D-alanine ligase -
QMM94_RS10490 (2130340) 2130340..2131542 + 1203 WP_001109944.1 FtsW/RodA/SpoVE family cell cycle protein -
QMM94_RS10495 (2131806) 2131806..2131943 - 138 WP_000828354.1 Lmo0850 family protein -
QMM94_RS10500 (2132071) 2132071..2132280 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QMM94_RS10505 (2132292) 2132292..2132585 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QMM94_RS10510 (2132751) 2132751..2134235 + 1485 WP_000571549.1 cardiolipin synthase -
QMM94_RS10515 (2134263) 2134263..2134910 + 648 WP_154283800.1 HD domain-containing protein -
QMM94_RS10520 (2135686) 2135686..2136558 - 873 WP_154283799.1 membrane protein insertase YidC -
QMM94_RS10525 (2136644) 2136644..2137285 - 642 WP_154283798.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T42988 WP_000581792.1 NZ_AP027134:c2132280-2132071 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T42988 NZ_AP027134:c2132280-2132071 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT42988 WP_000138932.1 NZ_AP027134:c2132585-2132292 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT42988 NZ_AP027134:c2132585-2132292 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References