Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2112315..2112844 Replicon chromosome
Accession NZ_AP027134
Organism Staphylococcus aureus strain JP008

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QMM94_RS10410 Protein ID WP_000621175.1
Coordinates 2112315..2112677 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QMM94_RS10415 Protein ID WP_000948330.1
Coordinates 2112674..2112844 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM94_RS10390 (2109294) 2109294..2110064 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
QMM94_RS10395 (2110039) 2110039..2110518 - 480 WP_001190825.1 anti-sigma B factor RsbW -
QMM94_RS10400 (2110520) 2110520..2110846 - 327 WP_001052491.1 anti-sigma factor antagonist -
QMM94_RS10405 (2110965) 2110965..2111966 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
QMM94_RS10410 (2112315) 2112315..2112677 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QMM94_RS10415 (2112674) 2112674..2112844 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QMM94_RS10420 (2112929) 2112929..2114077 - 1149 WP_001281148.1 alanine racemase -
QMM94_RS10425 (2114143) 2114143..2114502 - 360 WP_000581193.1 holo-ACP synthase -
QMM94_RS10430 (2114506) 2114506..2114997 - 492 WP_154283807.1 PH domain-containing protein -
QMM94_RS10435 (2114984) 2114984..2116567 - 1584 WP_209205797.1 PH domain-containing protein -
QMM94_RS10440 (2116560) 2116560..2117039 - 480 WP_154283805.1 hypothetical protein -
QMM94_RS10445 (2117248) 2117248..2117808 - 561 WP_154283804.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T42987 WP_000621175.1 NZ_AP027134:c2112677-2112315 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T42987 NZ_AP027134:c2112677-2112315 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT42987 WP_000948330.1 NZ_AP027134:c2112844-2112674 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT42987 NZ_AP027134:c2112844-2112674 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References