Detailed information of TA system TA042982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 831909..832438
• Replicon: chromosome
• Accession: NZ_AP027134
• Organism: Staphylococcus aureus strain JP008

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX2
• Locus tag: QMM94_RS03965
• Protein ID: WP_001103933.1
• Coordinates: 832121..832438 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: QMM94_RS03960
• Protein ID: WP_064132044.1
• Coordinates: 831909..832118 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM94_RS03930 (828069)	828069..829091	-	1023	Protein_761	site-specific integrase	-
QMM94_RS03935 (829105)	829105..830493	-	1389	WP_064132042.1	SAP domain-containing protein	-
QMM94_RS03940 (830520)	830520..831092	-	573	WP_281962001.1	helix-turn-helix transcriptional regulator	-
QMM94_RS03945 (831264)	831264..831485	+	222	WP_000560872.1	helix-turn-helix transcriptional regulator	-
QMM94_RS03950 (831486)	831486..831758	+	273	WP_000124597.1	helix-turn-helix domain-containing protein	-
QMM94_RS03955 (831770)	831770..831916	+	147	WP_000784885.1	hypothetical protein	-
QMM94_RS03960 (831909)	831909..832118	+	210	WP_064132044.1	hypothetical protein	Antitoxin
QMM94_RS03965 (832121)	832121..832438	+	318	WP_001103933.1	DUF1474 family protein	Toxin
QMM94_RS03970 (832505)	832505..833374	+	870	WP_077517454.1	primase alpha helix C-terminal domain-containing protein	-
QMM94_RS03975 (833388)	833388..835097	+	1710	WP_064132046.1	DUF927 domain-containing protein	-
QMM94_RS03980 (835427)	835427..835807	+	381	WP_000356930.1	hypothetical protein	-
QMM94_RS03985 (835804)	835804..836445	+	642	WP_064132047.1	pathogenicity island protein	-
QMM94_RS03990 (836792)	836792..837133	+	342	WP_001161492.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	791982..839447	47465

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12511.13 Da
• Isoelectric Point: 4.6364

>T42982 WP_001103933.1 NZ_AP027134:832121-832438 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Nucleotide

• Length: 318 bp

>T42982 NZ_AP027134:832121-832438 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.24 Da
• Isoelectric Point: 4.2820

>AT42982 WP_064132044.1 NZ_AP027134:831909-832118 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESNEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT42982 NZ_AP027134:831909-832118 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAGCACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTAA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: K7ZRX2