Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 13346..13989 Replicon plasmid pTEGF4
Accession NZ_AP027057
Organism Limnohabitans sp. TEGF004

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LINBF2_RS12955 Protein ID WP_281891431.1
Coordinates 13579..13989 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LINBF2_RS12950 Protein ID WP_281891430.1
Coordinates 13346..13579 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LINBF2_RS12915 (LTEGF4_25540) 8422..9187 - 766 Protein_9 DUF4158 domain-containing protein -
LINBF2_RS12920 9273..9734 - 462 Protein_10 recombinase family protein -
LINBF2_RS12925 (LTEGF4_25560) 9913..10203 + 291 WP_281891353.1 ribbon-helix-helix protein, CopG family -
LINBF2_RS12930 (LTEGF4_25570) 10191..10481 + 291 WP_281891354.1 type II toxin-antitoxin system RelE/ParE family toxin -
LINBF2_RS12935 (LTEGF4_25580) 10487..11022 + 536 Protein_13 transposase -
LINBF2_RS12940 (LTEGF4_25590) 12167..12559 + 393 WP_281891429.1 type II toxin-antitoxin system RelE/ParE family toxin -
LINBF2_RS12945 (LTEGF4_25600) 12564..12911 + 348 WP_281891482.1 XRE family transcriptional regulator -
LINBF2_RS12950 (LTEGF4_25610) 13346..13579 + 234 WP_281891430.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LINBF2_RS12955 (LTEGF4_25620) 13579..13989 + 411 WP_281891431.1 tRNA(fMet)-specific endonuclease VapC Toxin
LINBF2_RS12960 (LTEGF4_25630) 14427..14846 - 420 WP_281891432.1 hypothetical protein -
LINBF2_RS12965 (LTEGF4_25640) 14836..16041 - 1206 WP_281891433.1 hypothetical protein -
LINBF2_RS12970 16441..16700 - 260 Protein_20 tyrosine-type recombinase/integrase -
LINBF2_RS12975 16780..16929 + 150 Protein_21 helix-turn-helix domain-containing protein -
LINBF2_RS12980 (LTEGF4_25650) 17232..17450 + 219 WP_281891434.1 hypothetical protein -
LINBF2_RS12985 (LTEGF4_25660) 17458..17730 + 273 WP_281891435.1 type II toxin-antitoxin system RelE/ParE family toxin -
LINBF2_RS12990 (LTEGF4_25670) 18382..18972 - 591 WP_281891436.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..148919 148919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14945.25 Da        Isoelectric Point: 6.6359

>T42976 WP_281891431.1 NZ_AP027057:13579-13989 [Limnohabitans sp. TEGF004]
MLRYLLDTNIVIYVLKRRPVEVLFTFNANASRMAISSITLAELLHGAEKSSCVSDNLAAIEDFCSRLEVLPYGPKAAQHY
GVIRAALEKLGQPIGVNDMHIAAHARSEGLVLVTNNMGEFARVPALEAENWVHTAQ

Download         Length: 411 bp

>T42976 NZ_AP027057:13579-13989 [Limnohabitans sp. TEGF004]
ATGCTGCGTTACTTGCTGGACACCAACATCGTCATCTACGTGTTGAAGCGACGACCTGTCGAGGTACTTTTCACTTTCAA
CGCCAACGCCAGCCGCATGGCAATTTCCTCCATTACCCTCGCGGAACTCTTGCACGGTGCTGAGAAAAGCAGCTGCGTGA
GCGATAACCTGGCCGCTATCGAGGATTTTTGCAGCCGTCTAGAAGTTCTGCCCTATGGCCCCAAGGCCGCGCAGCATTAC
GGCGTCATTCGCGCCGCCTTGGAAAAACTCGGCCAGCCTATCGGTGTGAACGACATGCACATTGCAGCGCATGCTCGCAG
CGAAGGCCTGGTGCTGGTGACGAACAATATGGGGGAGTTCGCACGAGTGCCTGCTCTGGAGGCAGAGAACTGGGTCCACA
CAGCGCAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8632.80 Da        Isoelectric Point: 5.7835

>AT42976 WP_281891430.1 NZ_AP027057:13346-13579 [Limnohabitans sp. TEGF004]
MSIGTVFVNNRTQAVRLPLDVRLPEGVQKVEIRVKGNERIISPLGQTWDSFFLGGATVSDDFLPERATQHQPEREAL

Download         Length: 234 bp

>AT42976 NZ_AP027057:13346-13579 [Limnohabitans sp. TEGF004]
ATGTCCATCGGCACTGTTTTCGTCAATAACCGTACCCAGGCCGTTCGTCTGCCTTTGGACGTGCGTCTACCCGAGGGTGT
CCAAAAGGTAGAGATACGCGTCAAAGGTAACGAGCGCATCATCTCCCCCCTAGGCCAAACTTGGGACAGCTTCTTTCTGG
GCGGGGCCACAGTTAGCGACGACTTCCTGCCGGAGCGCGCTACCCAGCACCAGCCGGAGCGGGAGGCGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References