Detailed information of TA system TA042971

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 546003..546586
• Replicon: chromosome
• Accession: NZ_AP027055
• Organism: Limnohabitans sp. INBF002

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QMG15_RS02795
• Protein ID: WP_281789389.1
• Coordinates: 546332..546586 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: QMG15_RS02790
• Protein ID: WP_281789388.1
• Coordinates: 546003..546335 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG15_RS02770 (LINBF2_05540)	542481..543053	+	573	WP_281789384.1	PAAR domain-containing protein	-
QMG15_RS02775 (LINBF2_05550)	542992..543663	+	672	WP_281789385.1	hypothetical protein	-
QMG15_RS02780	543668..544183	+	516	WP_281789386.1	hypothetical protein	-
QMG15_RS02785 (LINBF2_05570)	544192..546006	-	1815	WP_281789387.1	exodeoxyribonuclease V subunit alpha	-
QMG15_RS02790 (LINBF2_05580)	546003..546335	-	333	WP_281789388.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QMG15_RS02795 (LINBF2_05590)	546332..546586	-	255	WP_281789389.1	type II toxin-antitoxin system HicA family toxin	Toxin
QMG15_RS02800 (LINBF2_05600)	546684..550295	-	3612	WP_281789390.1	exodeoxyribonuclease V subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-79)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9557.95 Da
• Isoelectric Point: 9.8624

>T42971 WP_281789389.1 NZ_AP027055:c546586-546332 [Limnohabitans sp. INBF002]
MKRKHQKTLDAIYARPVSANIKWRDIEALLVELGADISEREGSRIAVVLFDEVRVFHRPHPSPDTDKGAVASIRKWFEQH
GVAP

Nucleotide

• Length: 255 bp

>T42971 NZ_AP027055:c546586-546332 [Limnohabitans sp. INBF002]
ATGAAGCGAAAACACCAAAAAACCTTAGACGCCATTTACGCCCGTCCTGTCAGCGCCAACATTAAATGGCGCGACATTGA
AGCACTCTTGGTAGAGCTGGGCGCAGACATCAGCGAACGAGAAGGTAGCCGCATAGCAGTGGTGCTGTTTGATGAAGTCC
GCGTATTTCATCGGCCACACCCCTCGCCCGATACGGACAAAGGTGCAGTCGCCAGCATTCGCAAGTGGTTTGAGCAACAC
GGAGTCGCACCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12454.33 Da
• Isoelectric Point: 6.9832

>AT42971 WP_281789388.1 NZ_AP027055:c546335-546003 [Limnohabitans sp. INBF002]
MNLMTYNGYNAKIEYDAELDMFRGEILGLTGGADFYGKNPKELRAEFKKSLEVFLEICREKGIEPRRNFSGKFNLRIPTE
LHEKLAIVAQAEGKSINTLAQEALLQRVAA

Nucleotide

• Length: 333 bp

>AT42971 NZ_AP027055:c546335-546003 [Limnohabitans sp. INBF002]
ATGAATTTGATGACCTACAACGGCTACAACGCCAAGATTGAATACGACGCAGAGCTGGACATGTTCAGAGGCGAAATCTT
GGGCCTCACGGGCGGTGCCGACTTTTACGGCAAGAACCCAAAAGAACTGCGTGCTGAATTTAAAAAATCACTCGAGGTGT
TTTTAGAGATCTGCCGCGAAAAGGGCATTGAGCCGCGGCGCAACTTCTCGGGCAAGTTCAATTTGCGCATTCCTACTGAG
CTGCACGAAAAGCTGGCCATCGTCGCACAAGCCGAGGGCAAGAGCATCAACACCTTGGCGCAAGAGGCTTTGCTTCAACG
CGTGGCCGCATGA