Detailed information of TA system TA042968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2172405..2172964
• Replicon: chromosome
• Accession: NZ_AP027053
• Organism: Vibrio nigripulchritudo strain TUMSAT-V.nig3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U4DSV3
• Locus tag: QMG88_RS28385
• Protein ID: WP_004404011.1
• Coordinates: 2172686..2172964 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U4DQE1
• Locus tag: QMG88_RS28380
• Protein ID: WP_004404015.1
• Coordinates: 2172405..2172689 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG88_RS28360 (TUMSATVNIG3_55670)	2168288..2169322	+	1035	WP_281831339.1	iron ABC transporter permease	-
QMG88_RS28365 (TUMSATVNIG3_55680)	2169319..2170296	+	978	WP_004404023.1	iron chelate uptake ABC transporter family permease subunit	-
QMG88_RS28370 (TUMSATVNIG3_55690)	2170301..2171098	+	798	WP_080927995.1	ATP-binding cassette domain-containing protein	-
QMG88_RS28375 (TUMSATVNIG3_55700)	2171349..2172182	+	834	WP_281831341.1	inositol monophosphatase	-
QMG88_RS28380 (TUMSATVNIG3_55710)	2172405..2172689	+	285	WP_004404015.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
QMG88_RS28385 (TUMSATVNIG3_55720)	2172686..2172964	+	279	WP_004404011.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
QMG88_RS28390 (TUMSATVNIG3_55730)	2173014..2173298	-	285	WP_022599002.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
QMG88_RS28395	2173379..2174002	-	624	WP_281832766.1	DUF998 domain-containing protein	-
QMG88_RS28400 (TUMSATVNIG3_55740)	2174177..2174932	-	756	WP_281831345.1	uroporphyrinogen-III C-methyltransferase	-
QMG88_RS28405 (TUMSATVNIG3_55750)	2174985..2175794	-	810	WP_281831347.1	formate/nitrite transporter family protein	-
QMG88_RS28410 (TUMSATVNIG3_55760)	2175906..2176238	-	333	WP_004403996.1	nitrite reductase small subunit NirD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-72)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10837.54 Da
• Isoelectric Point: 4.4400

>T42968 WP_004404011.1 NZ_AP027053:2172686-2172964 [Vibrio nigripulchritudo]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDSLIEAKVENLLEQPLMGVQRNGIRGRLLIIPEVSIIVPYWVEGEVIRIL
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T42968 NZ_AP027053:2172686-2172964 [Vibrio nigripulchritudo]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAATCCTGATGCAGC
AGAGAAAACCGACAGCCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAGCAACCTCTTATGGGCGTGCAAAGAAACGGAA
TCCGTGGACGTTTACTCATTATTCCTGAGGTATCAATAATCGTACCGTACTGGGTTGAAGGCGAAGTTATCCGCATTCTG
CGTGTGCTCCACCAAAAACAAAAATTCCCTACAGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11022.34 Da
• Isoelectric Point: 8.0517

>AT42968 WP_004404015.1 NZ_AP027053:2172405-2172689 [Vibrio nigripulchritudo]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKLDSGKSVFVEHESAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT42968 NZ_AP027053:2172405-2172689 [Vibrio nigripulchritudo]
ATGGACACTAGAATTCAGTTTCGTGTTGATGAGGAAACAAAACGCTTAGCTCAGCAAATGGCTGAAAGTCAGGGTCGTAC
ATTGAGTGATGCTTGCCGAGAACTTACTGAACAACTCGCTGAACAACAAAGAAAAACACTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGCTTGACTCAGGAAAGTCGGTTTTCGTTGAACATGAATCGGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGCAACCGAGGTAAGCAATGA

Structures

Toxin

• AlphaFold DB: U4DSV3

Antitoxin

• AlphaFold DB: U4DQE1