Detailed information of TA system TA042966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 260877..261405
• Replicon: chromosome
• Accession: NZ_AP027052
• Organism: Vibrio nigripulchritudo strain TUMSAT-V.nig3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K5TRR0
• Locus tag: QMG88_RS01230
• Protein ID: WP_005377002.1
• Coordinates: 260877..261167 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U4K213
• Locus tag: QMG88_RS01235
• Protein ID: WP_022551768.1
• Coordinates: 261157..261405 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG88_RS01210 (TUMSATVNIG3_02150)	256432..257403	+	972	WP_281828318.1	PIN domain-containing protein	-
QMG88_RS01215 (TUMSATVNIG3_02160)	257540..258937	+	1398	WP_281828320.1	P-loop NTPase fold protein	-
QMG88_RS01220 (TUMSATVNIG3_02170)	259242..259562	+	321	WP_281828322.1	hypothetical protein	-
QMG88_RS01225 (TUMSATVNIG3_02180)	259590..260546	-	957	WP_281828324.1	IS110 family transposase	-
QMG88_RS01230 (TUMSATVNIG3_02190)	260877..261167	-	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QMG88_RS01235 (TUMSATVNIG3_02200)	261157..261405	-	249	WP_022551768.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
QMG88_RS01240	261462..261563	+	102	WP_281830421.1	DUF3265 domain-containing protein	-
QMG88_RS01245 (TUMSATVNIG3_02210)	261571..261945	+	375	WP_281828362.1	hypothetical protein	-
QMG88_RS01250 (TUMSATVNIG3_02220)	262267..262743	-	477	WP_281828364.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
QMG88_RS01255 (TUMSATVNIG3_02230)	262856..263467	-	612	WP_022551764.1	superoxide dismutase	-
QMG88_RS01260 (TUMSATVNIG3_02240)	263622..264989	-	1368	WP_281828367.1	envelope stress sensor histidine kinase CpxA	-
QMG88_RS01265 (TUMSATVNIG3_02250)	264989..265681	-	693	WP_004399825.1	response regulator	-
QMG88_RS01270 (TUMSATVNIG3_02260)	265863..266363	+	501	WP_281828370.1	CpxP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	251462..261945	10483
	-	flank	IS/Tn	-	-	259590..260546	956

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11261.25 Da
• Isoelectric Point: 10.5932

>T42966 WP_005377002.1 NZ_AP027052:c261167-260877 [Vibrio nigripulchritudo]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T42966 NZ_AP027052:c261167-260877 [Vibrio nigripulchritudo]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCGCTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGGAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9019.29 Da
• Isoelectric Point: 3.9610

>AT42966 WP_022551768.1 NZ_AP027052:c261405-261157 [Vibrio nigripulchritudo]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMVDKLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT42966 NZ_AP027052:c261405-261157 [Vibrio nigripulchritudo]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTATGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGG
TGGACAAACTCGAAGATCTTGAACTACTAGCTATAGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: A0A347UR03

Antitoxin

• AlphaFold DB: A0A6N3LLX4