Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 163127..164787 Replicon plasmid pTUMSAT-V.nig1-1
Accession NZ_AP027047
Organism Vibrio nigripulchritudo strain TUMSAT-V.nig1

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag QMG95_RS29280 Protein ID WP_200769003.1
Coordinates 163471..164787 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag QMG95_RS29275 Protein ID WP_200769002.1
Coordinates 163127..163477 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG95_RS29250 (TUMSATVNIG1_57650) 159071..159304 + 234 WP_200768999.1 type II toxin-antitoxin system VapB family antitoxin -
QMG95_RS29255 (TUMSATVNIG1_57660) 159318..159719 + 402 WP_200769018.1 type II toxin-antitoxin system VapC family toxin -
QMG95_RS29260 (TUMSATVNIG1_57670) 159733..159942 + 210 WP_200769000.1 hypothetical protein -
QMG95_RS29265 160076..161305 - 1230 WP_200769001.1 MFS transporter -
QMG95_RS29270 (TUMSATVNIG1_57700) 161580..162164 - 585 Protein_147 reverse transcriptase domain-containing protein -
QMG95_RS29275 (TUMSATVNIG1_57710) 163127..163477 + 351 WP_200769002.1 helix-turn-helix transcriptional regulator Antitoxin
QMG95_RS29280 (TUMSATVNIG1_57720) 163471..164787 + 1317 WP_200769003.1 type II toxin-antitoxin system HipA family toxin Toxin
QMG95_RS29285 (TUMSATVNIG1_57730) 165301..165483 + 183 WP_022614239.1 YegP family protein -
QMG95_RS29290 (TUMSATVNIG1_57740) 165935..167011 - 1077 WP_200769004.1 hypothetical protein -
QMG95_RS29295 (TUMSATVNIG1_57760) 167612..168694 + 1083 WP_225911892.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..351696 351696


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(175-412)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 48889.25 Da        Isoelectric Point: 5.6631

>T42960 WP_200769003.1 NZ_AP027047:163471-164787 [Vibrio nigripulchritudo]
MVDKKYDTAKVRIFGKDVGALAEDTTTGIVSFEYFDEWLKTGFAISQRLPLEAGTFSFPTLNYPTYKGLPAAFADTLPDD
FGNAVINAWLARQGRDPQSFRSLERLLYTGLRGMGALEYTPALSDTIKKQDESITIDSLVTMAQLVLDKRNNLDETIANE
QEAEQALTGILQVGTSAGGARAKAVIAVNSDRTQIRSGQVNAPKGFEHFLLKFDGVVERSSTSEVFGDPKGFGLMEYAYY
LMAKKAGIDISHCELLKENGRAHFMTKRFDRVGNEKVHYQSLCAMDHADFKQPGGYSYEELFTLLRSLRLDRLSALEVFR
RMAFNVIARNHDDHTKNWGFVINSANKWELAPAFDLAYSYKPGSPWVDSHQMSINGKRDNFTKQDLLGVVPPSLQGEAEA
ILSEVHATVATWREIAKDVGVEPSFIDEIESNHRLSLL

Download         Length: 1317 bp

>T42960 NZ_AP027047:163471-164787 [Vibrio nigripulchritudo]
TTGGTAGACAAGAAATACGACACAGCAAAGGTACGTATATTTGGTAAAGATGTCGGCGCTCTGGCTGAAGATACAACGAC
CGGAATCGTTAGCTTTGAATATTTCGATGAGTGGCTAAAAACTGGGTTTGCCATTTCACAAAGGCTCCCTCTTGAGGCTG
GCACGTTTAGTTTCCCCACTCTGAATTATCCAACCTATAAAGGTCTACCTGCAGCCTTCGCAGATACTCTACCCGATGAC
TTTGGTAATGCCGTAATCAATGCCTGGCTTGCACGCCAGGGTCGAGACCCACAATCTTTCCGTTCATTGGAAAGACTGCT
TTATACCGGCTTACGAGGTATGGGAGCTCTTGAGTACACACCCGCATTATCTGACACAATTAAAAAACAAGATGAATCAA
TTACAATCGACTCACTTGTGACAATGGCGCAACTCGTCCTTGACAAAAGAAACAACCTAGATGAAACCATCGCCAATGAG
CAGGAAGCGGAGCAGGCCTTAACTGGCATCCTTCAAGTCGGCACCTCAGCTGGAGGTGCCAGAGCTAAAGCTGTCATCGC
AGTCAACTCAGATCGCACGCAAATACGCTCGGGTCAGGTAAATGCCCCCAAAGGCTTCGAACACTTCCTATTAAAGTTTG
ATGGCGTTGTTGAACGCTCATCCACTAGTGAGGTATTTGGTGACCCTAAGGGCTTCGGTTTAATGGAATATGCCTATTAC
TTAATGGCAAAAAAAGCCGGTATCGATATCTCACATTGCGAACTATTAAAGGAAAACGGACGTGCTCACTTCATGACAAA
ACGGTTTGACCGCGTAGGAAACGAAAAAGTGCATTACCAATCTCTATGCGCTATGGATCACGCAGATTTCAAACAACCAG
GCGGTTACAGTTATGAAGAACTCTTCACCCTATTGCGCTCATTGAGACTTGATCGACTATCAGCACTTGAAGTGTTTAGA
CGCATGGCTTTTAACGTGATTGCCCGCAACCACGATGACCACACAAAAAATTGGGGATTCGTTATCAATAGTGCGAACAA
GTGGGAACTCGCGCCAGCATTCGACTTAGCATATAGCTACAAACCAGGCTCGCCTTGGGTAGACAGCCATCAAATGTCGA
TCAACGGTAAGCGAGACAATTTTACAAAACAAGATTTACTAGGAGTCGTACCTCCGTCACTACAAGGTGAGGCAGAAGCC
ATTTTAAGTGAGGTTCATGCCACAGTGGCAACATGGCGAGAAATAGCAAAAGACGTAGGTGTCGAACCATCATTCATTGA
CGAAATAGAGTCCAACCACAGACTCAGCTTACTATGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13140.28 Da        Isoelectric Point: 10.6732

>AT42960 WP_200769002.1 NZ_AP027047:163127-163477 [Vibrio nigripulchritudo]
MIKSNIYAMSDEALSSELGRRIERRRLNHRSPLTQAQLAKKAGISRSTYQNMIEGKSTLINVIKVLRVLDSLEGIESFLP
EPGISPVQLLKMKGKVRQRVKPTSTPPQPKEEDLDW

Download         Length: 351 bp

>AT42960 NZ_AP027047:163127-163477 [Vibrio nigripulchritudo]
ATGATAAAGTCGAATATATACGCAATGTCAGATGAAGCACTAAGCAGTGAACTTGGTCGTCGAATCGAAAGACGAAGACT
CAATCACCGTTCACCACTTACTCAGGCGCAGCTAGCAAAAAAGGCAGGAATCAGCCGGTCAACATACCAGAATATGATCG
AGGGTAAATCAACCCTAATAAACGTCATCAAGGTACTCAGAGTGTTAGACTCATTGGAAGGTATTGAATCTTTCCTACCA
GAACCTGGAATTAGCCCAGTACAACTTCTCAAAATGAAAGGGAAAGTACGACAAAGGGTAAAACCGACCTCAACGCCACC
ACAGCCTAAAGAGGAGGACTTAGATTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References