Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4949887..4950515 Replicon chromosome
Accession NZ_AP026979
Organism Nocardia cyriacigeorgica strain FMUBM48

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FMUAM_RS22980 Protein ID WP_194996317.1
Coordinates 4950105..4950515 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FMUAM_RS22975 Protein ID WP_163845921.1
Coordinates 4949887..4950108 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FMUAM_RS22965 (FMUBM48_46220) 4945889..4947607 - 1719 WP_281904533.1 hypothetical protein -
FMUAM_RS22970 (FMUBM48_46230) 4948016..4949629 - 1614 WP_194996316.1 hypothetical protein -
FMUAM_RS22975 (FMUBM48_46240) 4949887..4950108 + 222 WP_163845921.1 Arc family DNA-binding protein Antitoxin
FMUAM_RS22980 (FMUBM48_46250) 4950105..4950515 + 411 WP_194996317.1 type II toxin-antitoxin system VapC family toxin Toxin
FMUAM_RS22985 (FMUBM48_46260) 4950568..4951524 - 957 WP_280480774.1 alpha/beta hydrolase -
FMUAM_RS22990 (FMUBM48_46270) 4951710..4952780 - 1071 WP_194982854.1 Abi family protein -
FMUAM_RS22995 (FMUBM48_46280) 4952977..4954056 - 1080 WP_280480772.1 redox-regulated ATPase YchF -
FMUAM_RS23000 (FMUBM48_46290) 4954172..4955095 - 924 WP_281919943.1 zinc-binding dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Arc-like DNA binding domain

(12-41)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14869.75 Da        Isoelectric Point: 4.2784

>T42955 WP_194996317.1 NZ_AP026979:4950105-4950515 [Nocardia cyriacigeorgica]
VIIADTNVVSELFKPTPDPRVIAWLENATDVTITAVTVGEIWAGIENLPDGRRKTGLRELAEDLFSEFGAEIQDYDFAAA
HIYGQIVSARRRLGRPIGYADAQIASICAANGWPVATRNVKDFTDIGIEVINPWDG

Download         Length: 411 bp

>T42955 NZ_AP026979:4950105-4950515 [Nocardia cyriacigeorgica]
GTGATCATCGCCGATACCAACGTTGTATCGGAGCTGTTCAAGCCCACCCCCGATCCTCGTGTCATCGCGTGGCTGGAGAA
CGCAACCGACGTGACGATCACGGCGGTGACGGTTGGCGAGATCTGGGCGGGCATCGAGAACTTGCCGGACGGGCGGCGAA
AGACCGGGCTGCGGGAACTCGCCGAGGACCTGTTCAGCGAGTTCGGCGCGGAGATCCAGGACTACGACTTCGCGGCGGCC
CACATCTACGGCCAGATCGTTTCAGCCCGCCGCCGACTCGGCCGTCCGATCGGCTATGCCGACGCCCAGATCGCGTCCAT
CTGCGCCGCCAACGGATGGCCCGTCGCCACGCGAAACGTGAAGGACTTCACCGATATCGGTATCGAGGTGATCAACCCGT
GGGATGGTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8158.31 Da        Isoelectric Point: 5.8651

>AT42955 WP_163845921.1 NZ_AP026979:4949887-4950108 [Nocardia cyriacigeorgica]
MAGITIRDLDDDVKERLRRRAAAHGRSMEAEARAILSDAVKPKLLLRELYERSRPYAAELELPEQPEAGAASL

Download         Length: 222 bp

>AT42955 NZ_AP026979:4949887-4950108 [Nocardia cyriacigeorgica]
ATGGCTGGCATAACGATCCGCGATCTCGACGACGACGTCAAAGAACGGCTGCGGCGGCGAGCTGCTGCTCATGGCCGAAG
CATGGAGGCCGAGGCGCGCGCGATCCTGTCAGATGCCGTCAAGCCGAAGCTTCTGCTGCGCGAACTGTACGAACGCAGTC
GACCGTACGCAGCGGAATTGGAACTCCCCGAACAACCCGAGGCAGGAGCAGCGTCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References