Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3395121..3395662 Replicon chromosome
Accession NZ_AP026979
Organism Nocardia cyriacigeorgica strain FMUBM48

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FMUAM_RS15655 Protein ID WP_033247014.1
Coordinates 3395372..3395662 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag FMUAM_RS15650 Protein ID WP_280478890.1
Coordinates 3395121..3395375 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FMUAM_RS15625 (FMUBM48_31440) 3390369..3390749 - 381 WP_033247017.1 DUF5313 family protein -
FMUAM_RS15630 (FMUBM48_31450) 3390746..3392392 - 1647 WP_280478896.1 SulP family inorganic anion transporter -
FMUAM_RS15635 (FMUBM48_31460) 3392389..3394266 - 1878 WP_228780495.1 phosphoenolpyruvate carboxykinase (GTP) -
FMUAM_RS15640 (FMUBM48_31470) 3394373..3394675 - 303 WP_033247016.1 metalloregulator ArsR/SmtB family transcription factor -
FMUAM_RS15645 (FMUBM48_31480) 3394891..3395067 + 177 WP_280478892.1 hypothetical protein -
FMUAM_RS15650 (FMUBM48_31490) 3395121..3395375 + 255 WP_280478890.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FMUAM_RS15655 (FMUBM48_31500) 3395372..3395662 + 291 WP_033247014.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FMUAM_RS15660 3395709..3396272 - 564 WP_228780345.1 hypothetical protein -
FMUAM_RS15665 (FMUBM48_31530) 3396640..3397929 + 1290 WP_281919740.1 recombinase family protein -
FMUAM_RS15670 (FMUBM48_31540) 3398326..3398982 - 657 WP_280478884.1 hypothetical protein -
FMUAM_RS15675 (FMUBM48_31550) 3398964..3400556 - 1593 WP_281919741.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11043.47 Da        Isoelectric Point: 5.1004

>T42954 WP_033247014.1 NZ_AP026979:3395372-3395662 [Nocardia cyriacigeorgica]
VSRYLLSPAAQADIDNIFEFTCEQWGFEQAEKYVRELQYAIERAVANPGIGRACDEIRPGYRALPAGSHTLYYRINGDVI
DVVRILHQRMDIDRNL

Download         Length: 291 bp

>T42954 NZ_AP026979:3395372-3395662 [Nocardia cyriacigeorgica]
GTGAGCCGGTATCTTCTCTCCCCCGCCGCGCAGGCCGATATCGATAACATCTTCGAATTCACCTGCGAGCAATGGGGATT
CGAGCAGGCCGAGAAGTATGTACGCGAACTCCAGTACGCCATCGAGCGCGCCGTGGCGAACCCCGGCATCGGCCGGGCGT
GTGATGAGATCCGCCCCGGCTACCGTGCACTTCCCGCTGGATCACACACCCTCTACTACCGGATCAACGGGGACGTGATC
GATGTCGTGCGAATCCTGCACCAGCGCATGGACATCGACCGCAACCTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9114.98 Da        Isoelectric Point: 5.8212

>AT42954 WP_280478890.1 NZ_AP026979:3395121-3395375 [Nocardia cyriacigeorgica]
VGKNTSFSLDEHYSSFIDGEVASGRYRSASDVVRTALRLLEDRETQLRALRTALIDGENSGKSTPFDFDAFIASKRADGG
AGSR

Download         Length: 255 bp

>AT42954 NZ_AP026979:3395121-3395375 [Nocardia cyriacigeorgica]
GTGGGCAAGAACACCTCCTTCAGCCTCGACGAGCACTACAGCTCGTTCATCGACGGCGAGGTCGCCTCGGGCCGCTACCG
CTCGGCCAGCGACGTCGTCCGTACAGCACTGCGGCTGCTGGAAGATCGCGAGACTCAGTTGCGTGCCCTGCGCACCGCGC
TGATCGACGGGGAGAACAGCGGAAAGTCGACACCCTTCGACTTCGACGCCTTCATTGCCAGCAAACGGGCCGACGGCGGC
GCGGGCAGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References