Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1104666..1105249 Replicon chromosome
Accession NZ_AP026974
Organism Polynucleobacter yangtzensis strain KF032

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QMF30_RS05505 Protein ID WP_281744385.1
Coordinates 1104666..1105007 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QMF30_RS05510 Protein ID WP_281744387.1
Coordinates 1105007..1105249 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMF30_RS05475 (PKF032_10560) 1099749..1100603 + 855 WP_281744375.1 carboxylating nicotinate-nucleotide diphosphorylase -
QMF30_RS05480 (PKF032_10570) 1100679..1100969 + 291 WP_281744377.1 type II toxin-antitoxin system RelE/ParE family toxin -
QMF30_RS05485 (PKF032_10580) 1100978..1101286 + 309 WP_068323165.1 putative addiction module antidote protein -
QMF30_RS05490 (PKF032_10590) 1101294..1102667 - 1374 WP_281744379.1 TAXI family TRAP transporter solute-binding subunit -
QMF30_RS05495 (PKF032_10600) 1102736..1104394 - 1659 WP_281744381.1 L-aspartate oxidase -
QMF30_RS05500 (PKF032_10610) 1104436..1104651 - 216 WP_281744383.1 hypothetical protein -
QMF30_RS05505 (PKF032_10620) 1104666..1105007 - 342 WP_281744385.1 endoribonuclease MazF Toxin
QMF30_RS05510 (PKF032_10630) 1105007..1105249 - 243 WP_281744387.1 PbsX family transcriptional regulator Antitoxin
QMF30_RS05515 (PKF032_10640) 1105357..1108251 - 2895 WP_281744388.1 formate dehydrogenase subunit alpha -
QMF30_RS05520 (PKF032_10650) 1108292..1110094 - 1803 WP_281744390.1 NAD(P)H-dependent oxidoreductase subunit E -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-109)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12583.60 Da        Isoelectric Point: 9.0324

>T42952 WP_281744385.1 NZ_AP026974:c1105007-1104666 [Polynucleobacter yangtzensis]
MVRAYVPEAGDVVWLEFDPQAGREQAGRRPAVVLTPESYNKKTNLLVCCPLTTQIKGYPFEVLVEVDGVHSAILSDQVKS
LDWKIRKAKYKNTVNPEALTEVRAKVKSLLSIG

Download         Length: 342 bp

>T42952 NZ_AP026974:c1105007-1104666 [Polynucleobacter yangtzensis]
ATGGTTAGAGCTTACGTACCAGAGGCTGGTGATGTAGTGTGGCTAGAGTTTGACCCTCAGGCTGGAAGGGAGCAGGCTGG
CCGTCGGCCTGCTGTAGTGTTGACTCCTGAGAGCTATAACAAAAAAACGAATTTGTTGGTTTGCTGTCCATTAACAACTC
AGATTAAAGGTTACCCTTTTGAGGTGTTGGTTGAGGTCGATGGGGTCCACTCTGCCATCTTATCTGACCAAGTTAAGTCT
CTGGATTGGAAAATAAGAAAAGCAAAATATAAAAATACAGTGAATCCTGAGGCCCTCACTGAGGTAAGGGCTAAGGTGAA
ATCTTTGCTCTCTATAGGATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8751.25 Da        Isoelectric Point: 9.7703

>AT42952 WP_281744387.1 NZ_AP026974:c1105249-1105007 [Polynucleobacter yangtzensis]
MQTVIKKWGNSPALRLNAAVMKSAQLNIDQLVSVKVQKGRIVIEPIAKQEYPLNELLSGITAKNLHGEADFGEPVGKELL

Download         Length: 243 bp

>AT42952 NZ_AP026974:c1105249-1105007 [Polynucleobacter yangtzensis]
ATGCAAACAGTTATTAAAAAGTGGGGCAATAGCCCGGCTTTGCGCTTAAATGCTGCGGTCATGAAGTCCGCCCAATTAAA
TATTGATCAGCTTGTCTCTGTAAAAGTGCAGAAGGGTCGAATTGTGATTGAGCCAATCGCAAAACAAGAATATCCACTGA
ATGAGCTATTGTCCGGAATTACCGCTAAGAATTTGCACGGTGAAGCCGACTTTGGTGAGCCCGTAGGAAAAGAGCTTCTC
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References