Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1100679..1101286 Replicon chromosome
Accession NZ_AP026974
Organism Polynucleobacter yangtzensis strain KF032

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QMF30_RS05480 Protein ID WP_281744377.1
Coordinates 1100679..1100969 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A9C7FCB2
Locus tag QMF30_RS05485 Protein ID WP_068323165.1
Coordinates 1100978..1101286 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMF30_RS05460 (PKF032_10530) 1096407..1097840 + 1434 WP_281744370.1 HAMP domain-containing sensor histidine kinase -
QMF30_RS05465 (PKF032_10540) 1097848..1098492 + 645 WP_281744372.1 response regulator -
QMF30_RS05470 (PKF032_10550) 1098618..1099733 + 1116 WP_281744374.1 quinolinate synthase NadA -
QMF30_RS05475 (PKF032_10560) 1099749..1100603 + 855 WP_281744375.1 carboxylating nicotinate-nucleotide diphosphorylase -
QMF30_RS05480 (PKF032_10570) 1100679..1100969 + 291 WP_281744377.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMF30_RS05485 (PKF032_10580) 1100978..1101286 + 309 WP_068323165.1 putative addiction module antidote protein Antitoxin
QMF30_RS05490 (PKF032_10590) 1101294..1102667 - 1374 WP_281744379.1 TAXI family TRAP transporter solute-binding subunit -
QMF30_RS05495 (PKF032_10600) 1102736..1104394 - 1659 WP_281744381.1 L-aspartate oxidase -
QMF30_RS05500 (PKF032_10610) 1104436..1104651 - 216 WP_281744383.1 hypothetical protein -
QMF30_RS05505 (PKF032_10620) 1104666..1105007 - 342 WP_281744385.1 endoribonuclease MazF -
QMF30_RS05510 (PKF032_10630) 1105007..1105249 - 243 WP_281744387.1 PbsX family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-89)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11041.97 Da        Isoelectric Point: 10.5091

>T42951 WP_281744377.1 NZ_AP026974:1100679-1100969 [Polynucleobacter yangtzensis]
MHEIRKTEEFKAWLDTLNDLMGRAKIQARIKRLAEGNQGNVKSVGSKVFEMKIDFGPGYRIYYAKQENTVYLLLIGVSKR
TQVKDIQIAKLLAKNL

Download         Length: 291 bp

>T42951 NZ_AP026974:1100679-1100969 [Polynucleobacter yangtzensis]
ATGCACGAAATAAGGAAAACAGAAGAATTTAAAGCTTGGTTAGATACTCTGAATGACTTAATGGGAAGGGCAAAAATACA
AGCAAGAATTAAACGGCTAGCAGAAGGCAACCAAGGAAATGTGAAATCAGTTGGAAGCAAAGTCTTTGAAATGAAAATTG
ATTTTGGACCGGGCTACAGGATTTATTACGCAAAACAAGAGAATACGGTTTACCTTCTCCTTATCGGAGTCAGCAAAAGA
ACTCAGGTTAAGGATATTCAGATCGCTAAACTTTTGGCTAAAAATTTGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10943.76 Da        Isoelectric Point: 8.4982

>AT42951 WP_068323165.1 NZ_AP026974:1100978-1101286 [Polynucleobacter yangtzensis]
MEKTITSPYDVAEHLRTPKEMALYLQACIEESNGDAAFIARALGDIARAKGMAQVAKESGLSRESLYKALSGDRIPGFDT
VLKVLAALGLCLHAKPIGKIRA

Download         Length: 309 bp

>AT42951 NZ_AP026974:1100978-1101286 [Polynucleobacter yangtzensis]
ATGGAAAAAACGATTACCAGCCCCTATGATGTAGCAGAACATTTACGCACACCAAAAGAAATGGCACTTTATCTCCAGGC
ATGTATTGAGGAATCCAATGGAGATGCAGCTTTTATTGCCAGAGCACTTGGAGATATAGCGCGTGCCAAAGGAATGGCTC
AGGTAGCGAAAGAATCCGGACTATCAAGAGAAAGTCTTTATAAAGCGCTTTCTGGTGATCGCATACCTGGCTTTGATACG
GTCCTTAAAGTACTGGCAGCTCTTGGCCTATGTTTACATGCAAAGCCTATCGGCAAAATACGCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References