Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1294143..1294774 Replicon chromosome
Accession NZ_AP026973
Organism Polynucleobacter yangtzensis strain KF023

Toxin (Protein)


Gene name vapC Uniprot ID A0A9C7FIA3
Locus tag QMF28_RS06435 Protein ID WP_068323595.1
Coordinates 1294143..1294541 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMF28_RS06440 Protein ID WP_068323602.1
Coordinates 1294541..1294774 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMF28_RS06420 (PKF023_12300) 1290079..1290759 - 681 WP_281741795.1 outer membrane lipoprotein carrier protein LolA -
QMF28_RS06425 (PKF023_12310) 1290770..1293082 - 2313 WP_281741797.1 DNA translocase FtsK 4TM domain-containing protein -
QMF28_RS06430 (PKF023_12330) 1293122..1294078 + 957 WP_068323588.1 thioredoxin-disulfide reductase -
QMF28_RS06435 (PKF023_12340) 1294143..1294541 - 399 WP_068323595.1 type II toxin-antitoxin system VapC family toxin Toxin
QMF28_RS06440 (PKF023_12350) 1294541..1294774 - 234 WP_068323602.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QMF28_RS06445 (PKF023_12360) 1294877..1295032 - 156 WP_281741801.1 hypothetical protein -
QMF28_RS06450 (PKF023_12370) 1295127..1297187 - 2061 WP_068323605.1 sodium-translocating pyrophosphatase -
QMF28_RS06455 (PKF023_12380) 1297371..1297907 + 537 WP_068323609.1 inorganic diphosphatase -
QMF28_RS06460 (PKF023_12390) 1297942..1299561 + 1620 WP_281741804.1 NAD+ synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14977.34 Da        Isoelectric Point: 8.4537

>T42949 WP_068323595.1 NZ_AP026973:c1294541-1294143 [Polynucleobacter yangtzensis]
MLKYLLDTNIVIYVMKRKPLEVLKIFNKNANRMAISTITLAELMYGAEKSQQVESNLNNIEDFVSHLEVLPYDINATQHY
GQIKAFLESKGKPIGVNDIHIAAHARSHGLTLVTNNVSEFKRVPNLALENWV

Download         Length: 399 bp

>T42949 NZ_AP026973:c1294541-1294143 [Polynucleobacter yangtzensis]
ATGCTGAAGTACTTGCTAGATACCAATATTGTTATTTATGTAATGAAGCGAAAGCCACTGGAAGTGCTGAAGATCTTCAA
TAAAAATGCAAATCGAATGGCTATATCAACAATTACGTTAGCGGAGTTGATGTATGGTGCAGAAAAGAGTCAACAGGTTG
AAAGTAATCTTAATAACATTGAAGACTTTGTAAGTCATTTGGAAGTTTTACCTTATGACATAAATGCAACCCAGCATTAT
GGTCAAATTAAAGCATTCTTGGAGAGCAAGGGTAAGCCTATTGGAGTAAATGATATTCATATTGCAGCTCATGCTAGAAG
TCATGGCTTAACCCTAGTAACAAATAATGTATCCGAATTTAAAAGAGTCCCTAACCTTGCCCTTGAAAATTGGGTTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8952.09 Da        Isoelectric Point: 6.3219

>AT42949 WP_068323602.1 NZ_AP026973:c1294774-1294541 [Polynucleobacter yangtzensis]
MAISTVFTNNRTQAVRLPAEMRLPENVRKVNVRAKGRERIIAPIENMWDNYFLGDARVSDDFMNERGSQEQSDREPL

Download         Length: 234 bp

>AT42949 NZ_AP026973:c1294774-1294541 [Polynucleobacter yangtzensis]
ATGGCTATTTCAACTGTTTTTACAAATAACCGGACTCAAGCCGTGAGATTGCCTGCTGAAATGCGGCTGCCAGAAAATGT
TCGCAAGGTTAATGTTCGCGCAAAGGGTCGGGAGCGAATAATTGCCCCAATTGAAAACATGTGGGACAACTACTTTTTAG
GTGATGCTCGTGTAAGTGATGATTTTATGAATGAAAGAGGCTCTCAAGAGCAAAGCGATAGAGAGCCTCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References