Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 104762..105347 Replicon chromosome
Accession NZ_AP026973
Organism Polynucleobacter yangtzensis strain KF023

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QMF28_RS00610 Protein ID WP_281742612.1
Coordinates 105165..105347 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QMF28_RS00605 Protein ID WP_281742610.1
Coordinates 104762..105154 (-) Length 131 a.a.

Genomic Context

QMF28_RS00585QMF28_RS00590QMF28_RS00595QMF28_RS00600QMF28_RS00615QMF28_RS00620QMF28_RS00625QMF28_RS00630QMF28_RS00635QMF28_RS00640QMF28_RS00580QMF28_RS00605QMF28_RS00610QMF28_RS00645
Location: 101924..102511 (588 bp)
Type: Others
Protein ID: WP_068320186.1
Location: 102561..103217 (657 bp)
Type: Others
Protein ID: WP_281742604.1
Location: 103236..103997 (762 bp)
Type: Others
Protein ID: WP_281742606.1
Location: 103997..104755 (759 bp)
Type: Others
Protein ID: WP_281742608.1
Location: 105482..105877 (396 bp)
Type: Others
Protein ID: WP_281742614.1
Location: 105916..106317 (402 bp)
Type: Others
Protein ID: WP_281742615.1
Location: 106352..106708 (357 bp)
Type: Others
Protein ID: WP_281742618.1
Location: 106725..106946 (222 bp)
Type: Others
Protein ID: WP_215357717.1
Location: 106993..107469 (477 bp)
Type: Others
Protein ID: WP_281742620.1
Location: 107509..108291 (783 bp)
Type: Others
Protein ID: WP_281742622.1
Location: 100740..101807 (1068 bp)
Type: Others
Protein ID: WP_281742603.1
Location: 104762..105154 (393 bp)
Type: Antitoxin
Protein ID: WP_281742610.1
Location: 105165..105347 (183 bp)
Type: Toxin
Protein ID: WP_281742612.1
Location: 108288..109751 (1464 bp)
Type: Others
Protein ID: WP_281742623.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QMF28_RS00580 (PKF023_01040)100740..101807-1068WP_281742603.1histidinol-phosphate transaminase-
QMF28_RS00585 (PKF023_01050)101924..102511+588WP_068320186.1imidazoleglycerol-phosphate dehydratase HisB-
QMF28_RS00590 (PKF023_01060)102561..103217+657WP_281742604.1imidazole glycerol phosphate synthase subunit HisH-
QMF28_RS00595 (PKF023_01070)103236..103997+762WP_281742606.11-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase-
QMF28_RS00600 (PKF023_01080)103997..104755+759WP_281742608.1imidazole glycerol phosphate synthase subunit HisF-
QMF28_RS00605 (PKF023_01090)104762..105154-393WP_281742610.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
QMF28_RS00610 (PKF023_01100)105165..105347-183WP_281742612.1type II toxin-antitoxin system HicA family toxinToxin
QMF28_RS00615 (PKF023_01110)105482..105877+396WP_281742614.1phosphoribosyl-AMP cyclohydrolase-
QMF28_RS00620 (PKF023_01120)105916..106317+402WP_281742615.1phosphoribosyl-ATP diphosphatase-
QMF28_RS00625 (PKF023_01130)106352..106708+357WP_281742618.1histidine triad nucleotide-binding protein-
QMF28_RS00630 (PKF023_01140)106725..106946+222WP_215357717.1Sec-independent protein translocase subunit TatA-
QMF28_RS00635 (PKF023_01150)106993..107469+477WP_281742620.1Sec-independent protein translocase protein TatB-
QMF28_RS00640 (PKF023_01160)107509..108291+783WP_281742622.1twin-arginine translocase subunit TatC-
QMF28_RS00645 (PKF023_01170)108288..109751-1464WP_281742623.1sel1 repeat family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6647.89 Da        Isoelectric Point: 10.9710

>T42948 WP_281742612.1 NZ_AP026973:c105347-105165 [Polynucleobacter yangtzensis]
MNSKELIKALEKDGWILRGSKGSHHVFNHPFKAGHITVPHPKKDLGIGLVQKLLKQAGIK

Download         Length: 183 bp

>T42948 NZ_AP026973:c105347-105165 [Polynucleobacter yangtzensis]
ATGAATAGCAAAGAACTAATCAAGGCGCTAGAAAAAGATGGCTGGATTTTGCGGGGCTCAAAAGGCTCTCACCATGTTTT
TAATCACCCCTTTAAGGCTGGTCACATTACAGTGCCCCACCCTAAAAAGGATCTAGGAATTGGATTGGTTCAAAAGCTAC
TGAAACAAGCGGGCATCAAATAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14052.22 Da        Isoelectric Point: 4.7783

>AT42948 WP_281742610.1 NZ_AP026973:c105154-104762 [Polynucleobacter yangtzensis]
MKYPIAIEPGGDKAAWGVIVPDLPGCFSAADSGIDEAIENAKEAIELWIEMALDAGKDIPRPSPITNLQKKKEFKGYIWA
IAEIDPALLSDEIERVNITLPKRVLARLDAKAKSAGENRSAFIAHLAISA

Download         Length: 393 bp

>AT42948 NZ_AP026973:c105154-104762 [Polynucleobacter yangtzensis]
ATGAAATATCCAATTGCAATTGAACCAGGTGGCGATAAGGCGGCATGGGGCGTCATTGTTCCCGACTTACCAGGCTGTTT
CTCAGCTGCTGACAGCGGAATTGATGAGGCCATTGAAAACGCCAAAGAAGCGATCGAACTTTGGATTGAAATGGCATTGG
ATGCGGGCAAAGATATCCCCAGACCCAGCCCAATTACTAACCTGCAAAAGAAAAAGGAATTTAAGGGATATATTTGGGCC
ATTGCTGAAATTGATCCCGCCCTTCTTTCAGATGAAATTGAAAGAGTAAACATCACTCTGCCCAAAAGAGTGTTAGCAAG
GCTGGACGCTAAAGCTAAATCAGCCGGTGAAAATCGCTCTGCTTTTATTGCCCATTTAGCGATAAGCGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References