Detailed information of TA system TA042948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 104762..105347
• Replicon: chromosome
• Accession: NZ_AP026973
• Organism: Polynucleobacter yangtzensis strain KF023

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QMF28_RS00610
• Protein ID: WP_281742612.1
• Coordinates: 105165..105347 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: QMF28_RS00605
• Protein ID: WP_281742610.1
• Coordinates: 104762..105154 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMF28_RS00580 (PKF023_01040)	100740..101807	-	1068	WP_281742603.1	histidinol-phosphate transaminase	-
QMF28_RS00585 (PKF023_01050)	101924..102511	+	588	WP_068320186.1	imidazoleglycerol-phosphate dehydratase HisB	-
QMF28_RS00590 (PKF023_01060)	102561..103217	+	657	WP_281742604.1	imidazole glycerol phosphate synthase subunit HisH	-
QMF28_RS00595 (PKF023_01070)	103236..103997	+	762	WP_281742606.1	1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase	-
QMF28_RS00600 (PKF023_01080)	103997..104755	+	759	WP_281742608.1	imidazole glycerol phosphate synthase subunit HisF	-
QMF28_RS00605 (PKF023_01090)	104762..105154	-	393	WP_281742610.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QMF28_RS00610 (PKF023_01100)	105165..105347	-	183	WP_281742612.1	type II toxin-antitoxin system HicA family toxin	Toxin
QMF28_RS00615 (PKF023_01110)	105482..105877	+	396	WP_281742614.1	phosphoribosyl-AMP cyclohydrolase	-
QMF28_RS00620 (PKF023_01120)	105916..106317	+	402	WP_281742615.1	phosphoribosyl-ATP diphosphatase	-
QMF28_RS00625 (PKF023_01130)	106352..106708	+	357	WP_281742618.1	histidine triad nucleotide-binding protein	-
QMF28_RS00630 (PKF023_01140)	106725..106946	+	222	WP_215357717.1	Sec-independent protein translocase subunit TatA	-
QMF28_RS00635 (PKF023_01150)	106993..107469	+	477	WP_281742620.1	Sec-independent protein translocase protein TatB	-
QMF28_RS00640 (PKF023_01160)	107509..108291	+	783	WP_281742622.1	twin-arginine translocase subunit TatC	-
QMF28_RS00645 (PKF023_01170)	108288..109751	-	1464	WP_281742623.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6647.89 Da
• Isoelectric Point: 10.9710

>T42948 WP_281742612.1 NZ_AP026973:c105347-105165 [Polynucleobacter yangtzensis]
MNSKELIKALEKDGWILRGSKGSHHVFNHPFKAGHITVPHPKKDLGIGLVQKLLKQAGIK

Nucleotide

• Length: 183 bp

>T42948 NZ_AP026973:c105347-105165 [Polynucleobacter yangtzensis]
ATGAATAGCAAAGAACTAATCAAGGCGCTAGAAAAAGATGGCTGGATTTTGCGGGGCTCAAAAGGCTCTCACCATGTTTT
TAATCACCCCTTTAAGGCTGGTCACATTACAGTGCCCCACCCTAAAAAGGATCTAGGAATTGGATTGGTTCAAAAGCTAC
TGAAACAAGCGGGCATCAAATAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14052.22 Da
• Isoelectric Point: 4.7783

>AT42948 WP_281742610.1 NZ_AP026973:c105154-104762 [Polynucleobacter yangtzensis]
MKYPIAIEPGGDKAAWGVIVPDLPGCFSAADSGIDEAIENAKEAIELWIEMALDAGKDIPRPSPITNLQKKKEFKGYIWA
IAEIDPALLSDEIERVNITLPKRVLARLDAKAKSAGENRSAFIAHLAISA

Nucleotide

• Length: 393 bp

>AT42948 NZ_AP026973:c105154-104762 [Polynucleobacter yangtzensis]
ATGAAATATCCAATTGCAATTGAACCAGGTGGCGATAAGGCGGCATGGGGCGTCATTGTTCCCGACTTACCAGGCTGTTT
CTCAGCTGCTGACAGCGGAATTGATGAGGCCATTGAAAACGCCAAAGAAGCGATCGAACTTTGGATTGAAATGGCATTGG
ATGCGGGCAAAGATATCCCCAGACCCAGCCCAATTACTAACCTGCAAAAGAAAAAGGAATTTAAGGGATATATTTGGGCC
ATTGCTGAAATTGATCCCGCCCTTCTTTCAGATGAAATTGAAAGAGTAAACATCACTCTGCCCAAAAGAGTGTTAGCAAG
GCTGGACGCTAAAGCTAAATCAGCCGGTGAAAATCGCTCTGCTTTTATTGCCCATTTAGCGATAAGCGCTTAG