Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1200450..1201081 Replicon chromosome
Accession NZ_AP026972
Organism Polynucleobacter sp. KF022

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PKF022_RS06265 Protein ID WP_281776248.1
Coordinates 1200450..1200848 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PKF022_RS06270 Protein ID WP_281776249.1
Coordinates 1200848..1201081 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PKF022_RS06250 (PKF022_12100) 1196387..1197070 - 684 WP_281776245.1 outer membrane lipoprotein carrier protein LolA -
PKF022_RS06255 (PKF022_12110) 1197077..1199389 - 2313 WP_281776246.1 DNA translocase FtsK 4TM domain-containing protein -
PKF022_RS06260 (PKF022_12120) 1199429..1200385 + 957 WP_281776247.1 thioredoxin-disulfide reductase -
PKF022_RS06265 (PKF022_12130) 1200450..1200848 - 399 WP_281776248.1 type II toxin-antitoxin system VapC family toxin Toxin
PKF022_RS06270 (PKF022_12140) 1200848..1201081 - 234 WP_281776249.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PKF022_RS06275 (PKF022_12150) 1201142..1201339 - 198 WP_281776250.1 hypothetical protein -
PKF022_RS06280 (PKF022_12160) 1201443..1203503 - 2061 WP_281776251.1 sodium-translocating pyrophosphatase -
PKF022_RS06285 (PKF022_12170) 1203687..1204223 + 537 WP_281776252.1 inorganic diphosphatase -
PKF022_RS06290 (PKF022_12180) 1204258..1205877 + 1620 WP_281776253.1 NAD+ synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14892.23 Da        Isoelectric Point: 7.4637

>T42947 WP_281776248.1 NZ_AP026972:c1200848-1200450 [Polynucleobacter sp. KF022]
MLKYLLDTNLVIYVMKGKPLEVLKIFNKNANRMAISTITLAELMYGAEKSQQVESNLNNIEDFVSHLEVLPYDINATQHY
GQIKAFLESKGKPIGVNDIHIAAHARSHGLTLVTNNLSEFKRVPNLALENWV

Download         Length: 399 bp

>T42947 NZ_AP026972:c1200848-1200450 [Polynucleobacter sp. KF022]
ATGCTTAAGTACTTGCTAGATACCAATCTTGTTATTTATGTAATGAAGGGAAAGCCGCTGGAAGTGCTTAAGATCTTCAA
TAAAAATGCAAACCGAATGGCAATATCAACAATTACGTTGGCGGAGTTGATGTATGGCGCAGAAAAGAGTCAACAGGTTG
AAAGTAATCTTAATAACATTGAAGACTTTGTAAGTCATTTGGAAGTTTTACCTTATGACATAAATGCAACTCAGCATTAT
GGTCAAATTAAGGCATTCTTGGAGAGCAAGGGTAAGCCTATTGGAGTAAATGATATTCATATTGCGGCTCATGCTAGAAG
TCATGGTTTAACCCTGGTAACAAATAATCTATCCGAATTTAAAAGAGTCCCTAACCTTGCCCTTGAAAATTGGGTTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9021.20 Da        Isoelectric Point: 8.7150

>AT42947 WP_281776249.1 NZ_AP026972:c1201081-1200848 [Polynucleobacter sp. KF022]
MAISTVFTNNRTQAVRLPAEMRLPENVRKVNVRAKGRERIIAPIENMWDNYFLGDARVSDDFMNERGSQEQRDREPL

Download         Length: 234 bp

>AT42947 NZ_AP026972:c1201081-1200848 [Polynucleobacter sp. KF022]
TTGGCTATTTCAACAGTGTTTACCAACAACCGTACTCAGGCGGTGAGATTGCCTGCAGAAATGCGGCTGCCAGAAAATGT
TCGAAAGGTTAATGTTCGCGCAAAGGGTCGGGAGAGAATAATTGCCCCAATTGAAAACATGTGGGACAACTACTTTTTGG
GCGATGCCCGTGTAAGTGATGATTTTATGAATGAAAGAGGCTCTCAAGAGCAAAGAGATAGAGAGCCTCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References