Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 45443..45969 Replicon plasmid pSE20-C72-2-2
Accession NZ_AP026950
Organism Salmonella enterica strain SE20-72C-2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OO990_RS24715 Protein ID WP_000323025.1
Coordinates 45443..45730 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q5J3S4
Locus tag OO990_RS24720 Protein ID WP_000534857.1
Coordinates 45730..45969 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO990_RS24700 (SE2072C2_47450) 42975..43199 - 225 Protein_46 hypothetical protein -
OO990_RS24705 (SE2072C2_47460) 43338..44360 + 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
OO990_RS24710 (SE2072C2_47470) 44357..45139 + 783 WP_001531258.1 IS21-like element ISSen3 family helper ATPase IstB -
OO990_RS24715 (SE2072C2_47480) 45443..45730 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OO990_RS24720 (SE2072C2_47490) 45730..45969 - 240 WP_000534857.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OO990_RS24725 45994..46104 + 111 Protein_51 hypothetical protein -
OO990_RS24730 (SE2072C2_47500) 46243..46947 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
OO990_RS24735 (SE2072C2_47510) 47145..47360 + 216 WP_001112907.1 hypothetical protein -
OO990_RS24740 (SE2072C2_47520) 47363..48025 + 663 WP_000958205.1 lytic transglycosylase domain-containing protein -
OO990_RS24745 (SE2072C2_47530) 48036..48335 + 300 WP_000175462.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 - 1..74956 74956
- inside IScluster/Tn - - 43338..46947 3609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T42921 WP_000323025.1 NZ_AP026950:c45730-45443 [Salmonella enterica]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T42921 NZ_AP026950:c45730-45443 [Salmonella enterica]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9085.55 Da        Isoelectric Point: 4.6820

>AT42921 WP_000534857.1 NZ_AP026950:c45969-45730 [Salmonella enterica]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRKPKPVRVTLDEL

Download         Length: 240 bp

>AT42921 NZ_AP026950:c45969-45730 [Salmonella enterica]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE60

References