Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4030295..4030845 Replicon chromosome
Accession NZ_AP026948
Organism Salmonella enterica strain SE20-72C-2

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag OO990_RS19730 Protein ID WP_001199743.1
Coordinates 4030295..4030603 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag OO990_RS19735 Protein ID WP_000016243.1
Coordinates 4030606..4030845 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO990_RS19720 (SE2072C2_37950) 4025695..4029210 - 3516 WP_000342548.1 AAA domain-containing protein -
OO990_RS19725 4029572..4029873 - 302 Protein_3858 Arm DNA-binding domain-containing protein -
OO990_RS19730 (SE2072C2_37970) 4030295..4030603 - 309 WP_001199743.1 CcdB family protein Toxin
OO990_RS19735 (SE2072C2_37980) 4030606..4030845 - 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OO990_RS19740 (SE2072C2_37990) 4030954..4031178 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
OO990_RS19745 (SE2072C2_38000) 4031343..4032125 - 783 WP_001531258.1 IS21-like element ISSen3 family helper ATPase IstB -
OO990_RS19750 (SE2072C2_38010) 4032122..4033144 - 1023 WP_000627495.1 IS21-like element ISSen3 family transposase -
OO990_RS19755 4033335..4033495 - 161 Protein_3864 integrase -
OO990_RS19765 (SE2072C2_38020) 4033925..4034944 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
OO990_RS19770 (SE2072C2_38030) 4034972..4035502 - 531 WP_000896756.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T42915 WP_001199743.1 NZ_AP026948:c4030603-4030295 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T42915 NZ_AP026948:c4030603-4030295 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT42915 WP_000016243.1 NZ_AP026948:c4030845-4030606 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp

>AT42915 NZ_AP026948:c4030845-4030606 [Salmonella enterica]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTGCTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References