Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3389791..3390411 Replicon chromosome
Accession NZ_AP026948
Organism Salmonella enterica strain SE20-72C-2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OO990_RS16750 Protein ID WP_001280991.1
Coordinates 3390193..3390411 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OO990_RS16745 Protein ID WP_000344807.1
Coordinates 3389791..3390165 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO990_RS16735 (SE2072C2_32210) 3384930..3386123 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OO990_RS16740 (SE2072C2_32220) 3386146..3389295 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
OO990_RS16745 (SE2072C2_32230) 3389791..3390165 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OO990_RS16750 (SE2072C2_32240) 3390193..3390411 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OO990_RS16755 (SE2072C2_32250) 3390590..3391141 + 552 WP_001278791.1 maltose O-acetyltransferase -
OO990_RS16760 (SE2072C2_32260) 3391259..3391729 + 471 WP_000136183.1 YlaC family protein -
OO990_RS16765 3391785..3391925 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OO990_RS16770 (SE2072C2_32270) 3391931..3392191 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OO990_RS16775 (SE2072C2_32280) 3392416..3393966 + 1551 WP_000213134.1 EAL domain-containing protein -
OO990_RS16785 (SE2072C2_32290) 3394197..3394586 + 390 WP_000961285.1 MGMT family protein -
OO990_RS16790 (SE2072C2_32300) 3394619..3395188 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T42914 WP_001280991.1 NZ_AP026948:3390193-3390411 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T42914 NZ_AP026948:3390193-3390411 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT42914 WP_000344807.1 NZ_AP026948:3389791-3390165 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT42914 NZ_AP026948:3389791-3390165 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAAC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References