Detailed information of TA system TA042913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2354890..2355412
• Replicon: chromosome
• Accession: NZ_AP026948
• Organism: Salmonella enterica strain SE20-72C-2

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A5J1ICX1
• Locus tag: OO990_RS11495
• Protein ID: WP_000221344.1
• Coordinates: 2355128..2355412 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: OO990_RS11490
• Protein ID: WP_000885424.1
• Coordinates: 2354890..2355138 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO990_RS11460 (SE2072C2_22090)	2350059..2350274	+	216	WP_001530185.1	hypothetical protein	-
OO990_RS11465 (SE2072C2_22100)	2350708..2351631	+	924	WP_023230780.1	hypothetical protein	-
OO990_RS11470	2352046..2352621	+	576	Protein_2245	helix-turn-helix domain-containing protein	-
OO990_RS11475 (SE2072C2_22140)	2352692..2353642	-	951	WP_000941990.1	toll/interleukin-1 receptor domain-containing protein	-
OO990_RS11480 (SE2072C2_22150)	2353806..2354138	-	333	WP_000253166.1	DUF1493 family protein	-
OO990_RS11485 (SE2072C2_22160)	2354132..2354590	-	459	WP_000381836.1	hypothetical protein	-
OO990_RS11490 (SE2072C2_22170)	2354890..2355138	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OO990_RS11495 (SE2072C2_22180)	2355128..2355412	+	285	WP_000221344.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO990_RS11500 (SE2072C2_22190)	2355531..2355812	+	282	Protein_2251	RidA family protein	-
OO990_RS11505 (SE2072C2_22200)	2355864..2356943	-	1080	WP_000954705.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
OO990_RS11510 (SE2072C2_22210)	2357136..2357624	-	489	WP_001293633.1	MarR family winged helix-turn-helix transcriptional regulator	-
OO990_RS11515 (SE2072C2_22220)	2357669..2359177	+	1509	WP_000199421.1	FAD-dependent oxidoreductase	-
OO990_RS11520 (SE2072C2_22230)	2359167..2360408	+	1242	WP_001095723.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2347759..2362034	14275

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11015.73 Da
• Isoelectric Point: 10.5388

>T42913 WP_000221344.1 NZ_AP026948:2355128-2355412 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Nucleotide

• Length: 285 bp

>T42913 NZ_AP026948:2355128-2355412 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT42913 WP_000885424.1 NZ_AP026948:2354890-2355138 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT42913 NZ_AP026948:2354890-2355138 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A5J1ICX1

Antitoxin

• AlphaFold DB: A0A5I0WPN5