Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819448..820108 Replicon chromosome
Accession NZ_AP026948
Organism Salmonella enterica strain SE20-72C-2

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag OO990_RS03955 Protein ID WP_000244756.1
Coordinates 819695..820108 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag OO990_RS03950 Protein ID WP_000351186.1
Coordinates 819448..819714 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO990_RS03930 (SE2072C2_07690) 815377..816810 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
OO990_RS03935 (SE2072C2_07700) 816968..817279 + 312 WP_001182972.1 N(4)-acetylcytidine aminohydrolase -
OO990_RS03940 (SE2072C2_07710) 817443..818102 + 660 WP_000250289.1 hemolysin III family protein -
OO990_RS03945 (SE2072C2_07730) 818218..819198 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
OO990_RS03950 (SE2072C2_07750) 819448..819714 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
OO990_RS03955 (SE2072C2_07760) 819695..820108 + 414 WP_000244756.1 protein YgfX Toxin
OO990_RS03960 (SE2072C2_07770) 820161..820682 - 522 WP_001055885.1 flavodoxin FldB -
OO990_RS03965 (SE2072C2_07780) 820795..821691 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
OO990_RS03970 (SE2072C2_07790) 821715..822428 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OO990_RS03975 (SE2072C2_07800) 822434..824167 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T42904 WP_000244756.1 NZ_AP026948:819695-820108 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T42904 NZ_AP026948:819695-820108 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT42904 WP_000351186.1 NZ_AP026948:819448-819714 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT42904 NZ_AP026948:819448-819714 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References