Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 208869..209629 Replicon chromosome
Accession NZ_AP026948
Organism Salmonella enterica strain SE20-72C-2

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag OO990_RS00990 Protein ID WP_000533907.1
Coordinates 209144..209629 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag OO990_RS00985 Protein ID WP_000965886.1
Coordinates 208869..209156 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO990_RS00960 (SE2072C2_01890) 203958..204260 + 303 WP_000605592.1 YsaB family lipoprotein -
OO990_RS00965 (SE2072C2_01900) 204399..205310 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
OO990_RS00970 (SE2072C2_01910) 205320..207389 + 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
OO990_RS00975 207651..208082 + 432 Protein_193 IS3 family transposase -
OO990_RS00980 (SE2072C2_01920) 208224..208691 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
OO990_RS00985 (SE2072C2_01930) 208869..209156 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
OO990_RS00990 (SE2072C2_01940) 209144..209629 + 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
OO990_RS00995 (SE2072C2_01950) 210000..210539 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
OO990_RS01000 (SE2072C2_01960) 210712..210924 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
OO990_RS01005 (SE2072C2_01970) 211212..211502 - 291 WP_000455790.1 HTH-type transcriptional regulator -
OO990_RS01010 (SE2072C2_01980) 211941..212651 + 711 WP_000190524.1 DUF3053 domain-containing protein -
OO990_RS01015 (SE2072C2_01990) 212701..213675 - 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
OO990_RS01020 (SE2072C2_02000) 213905..214567 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T42903 WP_000533907.1 NZ_AP026948:209144-209629 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T42903 NZ_AP026948:209144-209629 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTATCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACTTTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT42903 WP_000965886.1 NZ_AP026948:208869-209156 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT42903 NZ_AP026948:208869-209156 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References