Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4722856..4723372 Replicon chromosome
Accession NZ_AP026913
Organism Klebsiella pneumoniae strain Kp21r_f22

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag kp21f22_RS23265 Protein ID WP_004192395.1
Coordinates 4722856..4723140 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag kp21f22_RS23270 Protein ID WP_004192397.1
Coordinates 4723130..4723372 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
kp21f22_RS23240 (4718273) 4718273..4718536 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
kp21f22_RS23245 (4718666) 4718666..4718839 + 174 WP_002886906.1 hypothetical protein -
kp21f22_RS23250 (4718842) 4718842..4719585 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
kp21f22_RS23255 (4719942) 4719942..4722080 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
kp21f22_RS23260 (4722388) 4722388..4722852 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
kp21f22_RS23265 (4722856) 4722856..4723140 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
kp21f22_RS23270 (4723130) 4723130..4723372 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
kp21f22_RS23275 (4723450) 4723450..4725360 - 1911 WP_004152270.1 PRD domain-containing protein -
kp21f22_RS23280 (4725383) 4725383..4726537 - 1155 WP_004178372.1 lactonase family protein -
kp21f22_RS23285 (4726604) 4726604..4727344 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T42873 WP_004192395.1 NZ_AP026913:c4723140-4722856 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T42873 NZ_AP026913:c4723140-4722856 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT42873 WP_004192397.1 NZ_AP026913:c4723372-4723130 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT42873 NZ_AP026913:c4723372-4723130 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References