Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 4636548..4637218 | Replicon | chromosome |
| Accession | NZ_AP026913 | ||
| Organism | Klebsiella pneumoniae strain Kp21r_f22 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A483GLH7 |
| Locus tag | kp21f22_RS22870 | Protein ID | WP_023301398.1 |
| Coordinates | 4636548..4636880 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A483GII7 |
| Locus tag | kp21f22_RS22875 | Protein ID | WP_023301397.1 |
| Coordinates | 4636901..4637218 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| kp21f22_RS22845 (4631773) | 4631773..4632445 | + | 673 | Protein_4476 | DUF4400 domain-containing protein | - |
| kp21f22_RS22850 (4632456) | 4632456..4633340 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| kp21f22_RS22855 (4633539) | 4633539..4633727 | - | 189 | Protein_4478 | transposase | - |
| kp21f22_RS22860 (4633744) | 4633744..4634855 | - | 1112 | Protein_4479 | IS3 family transposase | - |
| kp21f22_RS22865 (4635254) | 4635254..4636114 | - | 861 | WP_023301399.1 | hypothetical protein | - |
| kp21f22_RS22870 (4636548) | 4636548..4636880 | - | 333 | WP_023301398.1 | TA system toxin CbtA family protein | Toxin |
| kp21f22_RS22875 (4636901) | 4636901..4637218 | - | 318 | WP_023301397.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| kp21f22_RS22880 (4637237) | 4637237..4637458 | - | 222 | WP_023301396.1 | DUF987 domain-containing protein | - |
| kp21f22_RS22885 (4637467) | 4637467..4637949 | - | 483 | WP_023301395.1 | RadC family protein | - |
| kp21f22_RS22890 (4637958) | 4637958..4638416 | - | 459 | WP_023301394.1 | antirestriction protein | - |
| kp21f22_RS22895 (4638502) | 4638502..4638738 | - | 237 | WP_032446575.1 | DUF905 domain-containing protein | - |
| kp21f22_RS22900 (4638816) | 4638816..4639226 | - | 411 | WP_023301393.1 | hypothetical protein | - |
| kp21f22_RS22905 (4639293) | 4639293..4639730 | - | 438 | WP_023301392.1 | hypothetical protein | - |
| kp21f22_RS22910 (4639772) | 4639772..4640308 | - | 537 | WP_023301391.1 | DUF4339 domain-containing protein | - |
| kp21f22_RS22915 (4640334) | 4640334..4641044 | - | 711 | WP_023301390.1 | DeoR family transcriptional regulator | - |
| kp21f22_RS22920 (4641253) | 4641253..4642077 | - | 825 | WP_023301389.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12610.65 Da Isoelectric Point: 5.6692
>T42872 WP_023301398.1 NZ_AP026913:c4636880-4636548 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM
Download Length: 333 bp
>T42872 NZ_AP026913:c4636880-4636548 [Klebsiella pneumoniae]
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11785.37 Da Isoelectric Point: 6.6277
>AT42872 WP_023301397.1 NZ_AP026913:c4637218-4636901 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR
Download Length: 318 bp
>AT42872 NZ_AP026913:c4637218-4636901 [Klebsiella pneumoniae]
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483GLH7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483GII7 |