Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4726892..4727408 Replicon chromosome
Accession NZ_AP026912
Organism Klebsiella pneumoniae strain Kp21_f22

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag OO849_RS23290 Protein ID WP_004192395.1
Coordinates 4726892..4727176 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag OO849_RS23295 Protein ID WP_004192397.1
Coordinates 4727166..4727408 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO849_RS23265 (4722309) 4722309..4722572 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OO849_RS23270 (4722702) 4722702..4722875 + 174 WP_002886906.1 hypothetical protein -
OO849_RS23275 (4722878) 4722878..4723621 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OO849_RS23280 (4723978) 4723978..4726116 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OO849_RS23285 (4726424) 4726424..4726888 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OO849_RS23290 (4726892) 4726892..4727176 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO849_RS23295 (4727166) 4727166..4727408 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OO849_RS23300 (4727486) 4727486..4729396 - 1911 WP_004152270.1 PRD domain-containing protein -
OO849_RS23305 (4729419) 4729419..4730573 - 1155 WP_004178372.1 lactonase family protein -
OO849_RS23310 (4730640) 4730640..4731380 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T42853 WP_004192395.1 NZ_AP026912:c4727176-4726892 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T42853 NZ_AP026912:c4727176-4726892 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT42853 WP_004192397.1 NZ_AP026912:c4727408-4727166 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT42853 NZ_AP026912:c4727408-4727166 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References