Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4640701..4641371 Replicon chromosome
Accession NZ_AP026912
Organism Klebsiella pneumoniae strain Kp21_f22

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag OO849_RS22895 Protein ID WP_023301398.1
Coordinates 4640701..4641033 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag OO849_RS22900 Protein ID WP_023301397.1
Coordinates 4641054..4641371 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO849_RS22870 (4635926) 4635926..4636598 + 673 Protein_4481 DUF4400 domain-containing protein -
OO849_RS22875 (4636609) 4636609..4637493 + 885 WP_004192285.1 RES domain-containing protein -
OO849_RS22880 (4637692) 4637692..4637880 - 189 Protein_4483 transposase -
OO849_RS22885 (4637897) 4637897..4639008 - 1112 Protein_4484 IS3 family transposase -
OO849_RS22890 (4639407) 4639407..4640267 - 861 WP_023301399.1 hypothetical protein -
OO849_RS22895 (4640701) 4640701..4641033 - 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
OO849_RS22900 (4641054) 4641054..4641371 - 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OO849_RS22905 (4641390) 4641390..4641611 - 222 WP_023301396.1 DUF987 domain-containing protein -
OO849_RS22910 (4641620) 4641620..4642102 - 483 WP_023301395.1 RadC family protein -
OO849_RS22915 (4642111) 4642111..4642569 - 459 WP_023301394.1 antirestriction protein -
OO849_RS22920 (4642655) 4642655..4642891 - 237 WP_032446575.1 DUF905 domain-containing protein -
OO849_RS22925 (4642969) 4642969..4643379 - 411 WP_023301393.1 hypothetical protein -
OO849_RS22930 (4643446) 4643446..4643883 - 438 WP_023301392.1 hypothetical protein -
OO849_RS22935 (4643925) 4643925..4644461 - 537 WP_023301391.1 DUF4339 domain-containing protein -
OO849_RS22940 (4644487) 4644487..4645197 - 711 WP_023301390.1 DeoR family transcriptional regulator -
OO849_RS22945 (4645406) 4645406..4646230 - 825 WP_023301389.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T42852 WP_023301398.1 NZ_AP026912:c4641033-4640701 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T42852 NZ_AP026912:c4641033-4640701 [Klebsiella pneumoniae]
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT42852 WP_023301397.1 NZ_AP026912:c4641371-4641054 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT42852 NZ_AP026912:c4641371-4641054 [Klebsiella pneumoniae]
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References