Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 10307..10808 | Replicon | plasmid pMY732-2 |
| Accession | NZ_AP026909 | ||
| Organism | Escherichia coli strain MY732 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | MY015_RS24780 | Protein ID | WP_000702247.1 |
| Coordinates | 10307..10567 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | MY015_RS24785 | Protein ID | WP_001132407.1 |
| Coordinates | 10557..10808 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MY015_RS24735 (MY016_47700) | 5845..5997 | + | 153 | Protein_7 | FlmC family protein | - |
| MY015_RS24740 | 5945..6064 | + | 120 | WP_228932012.1 | Hok/Gef family protein | - |
| MY015_RS24745 (MY016_47710) | 6214..6810 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| MY015_RS24750 (MY016_47720) | 6828..7112 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| MY015_RS24755 (MY016_47730) | 7186..7851 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| MY015_RS24760 (MY016_47740) | 8449..8778 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| MY015_RS24765 (MY016_47750) | 9360..9683 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| MY015_RS24770 (MY016_47760) | 9725..9934 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| MY015_RS24775 (MY016_47770) | 10031..10255 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| MY015_RS24780 (MY016_47780) | 10307..10567 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| MY015_RS24785 (MY016_47790) | 10557..10808 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| MY015_RS24790 (MY016_47800) | 11358..11636 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| MY015_RS24795 (MY016_47820) | 12056..12322 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MY015_RS24800 (MY016_47830) | 12429..12872 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| MY015_RS24805 (MY016_47840) | 13169..13351 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| MY015_RS24810 (MY016_47850) | 13376..13813 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MY015_RS24815 (MY016_47860) | 13944..14270 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| MY015_RS24820 (MY016_47870) | 14290..14997 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| MY015_RS24825 (MY016_47880) | 14999..15751 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61498 | 61498 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T42834 WP_000702247.1 NZ_AP026909:10307-10567 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T42834 NZ_AP026909:10307-10567 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT42834 WP_001132407.1 NZ_AP026909:10557-10808 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT42834 NZ_AP026909:10557-10808 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|