Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4363773..4364368 Replicon chromosome
Accession NZ_AP026907
Organism Escherichia coli strain MY732

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag MY015_RS21225 Protein ID WP_000239579.1
Coordinates 4363773..4364123 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag MY015_RS21230 Protein ID WP_001223207.1
Coordinates 4364117..4364368 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY015_RS21205 (4359049) 4359049..4360071 - 1023 WP_001296689.1 ABC transporter permease -
MY015_RS21210 (4360085) 4360085..4361587 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
MY015_RS21215 (4361897) 4361897..4362853 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
MY015_RS21220 (4363163) 4363163..4363693 + 531 WP_000055072.1 inorganic diphosphatase -
MY015_RS21225 (4363773) 4363773..4364123 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
MY015_RS21230 (4364117) 4364117..4364368 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
MY015_RS21235 (4364581) 4364581..4364922 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
MY015_RS21240 (4364925) 4364925..4368704 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T42828 WP_000239579.1 NZ_AP026907:c4364123-4363773 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T42828 NZ_AP026907:c4364123-4363773 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT42828 WP_001223207.1 NZ_AP026907:c4364368-4364117 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT42828 NZ_AP026907:c4364368-4364117 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References