Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 41103..41842 Replicon plasmid pKAM576_1
Accession NZ_AP026887
Organism Enterobacter asburiae strain KAM576

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag OO861_RS24080 Protein ID WP_013087269.1
Coordinates 41357..41842 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag OO861_RS24075 Protein ID WP_007869691.1
Coordinates 41103..41369 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO861_RS24060 (37379) 37379..37705 + 327 WP_023327699.1 hypothetical protein -
OO861_RS24065 (37680) 37680..38486 - 807 WP_023327700.1 DUF4225 domain-containing protein -
OO861_RS24070 (39437) 39437..40450 - 1014 WP_023327701.1 plasmid replication initiator RepA -
OO861_RS24075 (41103) 41103..41369 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
OO861_RS24080 (41357) 41357..41842 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
OO861_RS24085 (42043) 42043..42654 - 612 WP_223998213.1 hypothetical protein -
OO861_RS24090 (42667) 42667..43077 - 411 WP_023327703.1 hypothetical protein -
OO861_RS24095 (43280) 43280..44549 - 1270 Protein_48 type II toxin-antitoxin system HipA family toxin -
OO861_RS24100 (44554) 44554..44847 - 294 WP_032636197.1 helix-turn-helix transcriptional regulator -
OO861_RS24105 (45248) 45248..46636 - 1389 WP_023327706.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..100532 100532


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T42805 WP_013087269.1 NZ_AP026887:41357-41842 [Enterobacter asburiae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T42805 NZ_AP026887:41357-41842 [Enterobacter asburiae]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT42805 WP_007869691.1 NZ_AP026887:41103-41369 [Enterobacter asburiae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT42805 NZ_AP026887:41103-41369 [Enterobacter asburiae]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References