Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4065856..4066513 Replicon chromosome
Accession NZ_AP026886
Organism Enterobacter asburiae strain KAM576

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag OO861_RS19770 Protein ID WP_021242050.1
Coordinates 4065856..4066266 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag OO861_RS19775 Protein ID WP_010435322.1
Coordinates 4066247..4066513 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO861_RS19750 (KAM576c_38700) 4061849..4063582 - 1734 WP_069303274.1 single-stranded-DNA-specific exonuclease RecJ -
OO861_RS19755 (KAM576c_38710) 4063588..4064301 - 714 WP_047060452.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OO861_RS19760 (KAM576c_38720) 4064330..4065226 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
OO861_RS19765 (KAM576c_38730) 4065328..4065849 + 522 WP_023309099.1 flavodoxin FldB -
OO861_RS19770 (KAM576c_38740) 4065856..4066266 - 411 WP_021242050.1 protein YgfX Toxin
OO861_RS19775 (KAM576c_38750) 4066247..4066513 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
OO861_RS19780 (KAM576c_38760) 4066808..4067788 + 981 WP_033146590.1 tRNA-modifying protein YgfZ -
OO861_RS19785 (KAM576c_38770) 4067863..4068522 - 660 WP_023309101.1 hemolysin III family protein -
OO861_RS19790 (KAM576c_38780) 4068688..4068999 - 312 WP_047060448.1 N(4)-acetylcytidine aminohydrolase -
OO861_RS19795 (KAM576c_38790) 4069051..4069782 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
OO861_RS19800 (KAM576c_38800) 4069899..4071332 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T42803 WP_021242050.1 NZ_AP026886:c4066266-4065856 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T42803 NZ_AP026886:c4066266-4065856 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGATAGTATGGATGCTGCCGAGTGGCGGGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT42803 WP_010435322.1 NZ_AP026886:c4066513-4066247 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT42803 NZ_AP026886:c4066513-4066247 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References