Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1034668..1035288 Replicon chromosome
Accession NZ_AP026886
Organism Enterobacter asburiae strain KAM576

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag OO861_RS04850 Protein ID WP_008499287.1
Coordinates 1034668..1034886 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag OO861_RS04855 Protein ID WP_008499288.1
Coordinates 1034914..1035288 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO861_RS04820 (KAM576c_09390) 1030682..1030942 + 261 WP_047061249.1 type B 50S ribosomal protein L31 -
OO861_RS04825 1030945..1031085 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OO861_RS04830 (KAM576c_09400) 1031082..1031792 - 711 WP_048975521.1 GNAT family protein -
OO861_RS04835 (KAM576c_09410) 1031894..1033354 + 1461 WP_069303749.1 PLP-dependent aminotransferase family protein -
OO861_RS04840 (KAM576c_09420) 1033326..1033793 - 468 WP_023310598.1 YlaC family protein -
OO861_RS04845 (KAM576c_09430) 1033911..1034462 - 552 WP_182383121.1 maltose O-acetyltransferase -
OO861_RS04850 (KAM576c_09440) 1034668..1034886 - 219 WP_008499287.1 HHA domain-containing protein Toxin
OO861_RS04855 (KAM576c_09450) 1034914..1035288 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
OO861_RS04860 (KAM576c_09460) 1035800..1038946 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
OO861_RS04865 (KAM576c_09470) 1038969..1040162 - 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T42791 WP_008499287.1 NZ_AP026886:c1034886-1034668 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T42791 NZ_AP026886:c1034886-1034668 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAGCTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT42791 WP_008499288.1 NZ_AP026886:c1035288-1034914 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT42791 NZ_AP026886:c1035288-1034914 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAATCATGGCTGGGTAAACGACCCAACATCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References