Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4486606..4487198 Replicon chromosome
Accession NZ_AP026873
Organism Enterobacter roggenkampii strain KAM546

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OO938_RS22105 Protein ID WP_084832869.1
Coordinates 4486606..4486977 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OO938_RS22110 Protein ID WP_264883934.1
Coordinates 4486980..4487198 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO938_RS22090 (KAM546c_43620) 4484106..4485008 + 903 WP_008501831.1 formate dehydrogenase subunit beta -
OO938_RS22095 (KAM546c_43630) 4485005..4485640 + 636 WP_008501832.1 formate dehydrogenase cytochrome b556 subunit -
OO938_RS22100 (KAM546c_43640) 4485637..4486566 + 930 WP_264881794.1 formate dehydrogenase accessory protein FdhE -
OO938_RS22105 (KAM546c_43650) 4486606..4486977 - 372 WP_084832869.1 type II toxin-antitoxin system VapC family toxin Toxin
OO938_RS22110 (KAM546c_43660) 4486980..4487198 - 219 WP_264883934.1 ribbon-helix-helix protein, CopG family Antitoxin
OO938_RS22115 (KAM546c_43670) 4487242..4488210 - 969 WP_264880207.1 IS5-like element IS903B family transposase -
OO938_RS22120 (KAM546c_43690) 4488240..4488959 + 720 Protein_4313 alpha/beta hydrolase -
OO938_RS22125 (KAM546c_43700) 4488968..4489909 - 942 WP_264881799.1 fatty acid biosynthesis protein FabY -
OO938_RS22130 (KAM546c_43710) 4489954..4490391 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
OO938_RS22135 (KAM546c_43720) 4490388..4491269 - 882 WP_021242790.1 virulence factor BrkB family protein -
OO938_RS22140 (KAM546c_43730) 4491263..4491862 - 600 WP_008501839.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-41)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13700.81 Da        Isoelectric Point: 6.3290

>T42785 WP_084832869.1 NZ_AP026873:c4486977-4486606 [Enterobacter roggenkampii]
MEHMAVFDTNILIDLFNNRVEAADAIENTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T42785 NZ_AP026873:c4486977-4486606 [Enterobacter roggenkampii]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GAATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTGATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCAGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATCGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATCCTAGCTACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8580.62 Da        Isoelectric Point: 4.4692

>AT42785 WP_264883934.1 NZ_AP026873:c4487198-4486980 [Enterobacter roggenkampii]
IQQSLIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 219 bp

>AT42785 NZ_AP026873:c4487198-4486980 [Enterobacter roggenkampii]
ATTCAACAAAGCCTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAACCTCAAGCAATTGCGAAATCAACCACG
TGCTGAACTGCTTCGCGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTGTTATCCGAAATGCGCTTGGTCTGT
GGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References