Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3669777..3670434 Replicon chromosome
Accession NZ_AP026873
Organism Enterobacter roggenkampii strain KAM546

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag OO938_RS18135 Protein ID WP_021242050.1
Coordinates 3669777..3670187 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag OO938_RS18140 Protein ID WP_006178375.1
Coordinates 3670168..3670434 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO938_RS18115 (KAM546c_35840) 3665770..3667503 - 1734 WP_264881271.1 single-stranded-DNA-specific exonuclease RecJ -
OO938_RS18120 (KAM546c_35850) 3667509..3668222 - 714 WP_008499708.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OO938_RS18125 (KAM546c_35860) 3668251..3669147 - 897 WP_264881273.1 site-specific tyrosine recombinase XerD -
OO938_RS18130 (KAM546c_35870) 3669249..3669770 + 522 WP_008499710.1 flavodoxin FldB -
OO938_RS18135 (KAM546c_35880) 3669777..3670187 - 411 WP_021242050.1 protein YgfX Toxin
OO938_RS18140 (KAM546c_35890) 3670168..3670434 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
OO938_RS18145 (KAM546c_35900) 3670729..3671709 + 981 WP_045351721.1 tRNA-modifying protein YgfZ -
OO938_RS18150 (KAM546c_35910) 3671794..3672453 - 660 WP_264881276.1 hemolysin III family protein -
OO938_RS18155 (KAM546c_35920) 3672719..3673450 + 732 WP_264883886.1 MurR/RpiR family transcriptional regulator -
OO938_RS18160 (KAM546c_35930) 3673567..3675000 + 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T42782 WP_021242050.1 NZ_AP026873:c3670187-3669777 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T42782 NZ_AP026873:c3670187-3669777 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGGTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAGCAGACGA
CGCAGGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT42782 WP_006178375.1 NZ_AP026873:c3670434-3670168 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT42782 NZ_AP026873:c3670434-3670168 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTCCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References