Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 233856..234452 Replicon chromosome
Accession NZ_AP026873
Organism Enterobacter roggenkampii strain KAM546

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag OO938_RS01070 Protein ID WP_023293553.1
Coordinates 234150..234452 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag OO938_RS01065 Protein ID WP_021242718.1
Coordinates 233856..234143 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO938_RS01060 (KAM546c_02050) 232228..233859 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
OO938_RS01065 (KAM546c_02060) 233856..234143 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
OO938_RS01070 (KAM546c_02070) 234150..234452 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO938_RS01075 (KAM546c_02080) 234650..235522 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
OO938_RS01080 (KAM546c_02090) 235523..235795 - 273 WP_014830263.1 DUF3811 domain-containing protein -
OO938_RS01085 (KAM546c_02100) 235846..236790 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
OO938_RS01090 (KAM546c_02110) 236896..238470 - 1575 WP_264882011.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T42769 WP_023293553.1 NZ_AP026873:c234452-234150 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T42769 NZ_AP026873:c234452-234150 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT42769 WP_021242718.1 NZ_AP026873:c234143-233856 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT42769 NZ_AP026873:c234143-233856 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References