42765

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3683509..3684158 Replicon chromosome
Accession NZ_AP026827
Organism Proteus mirabilis strain NUITM-VP1

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag OO779_RS17210 Protein ID WP_012368534.1
Coordinates 3683509..3683928 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag OO779_RS17215 Protein ID WP_012368535.1
Coordinates 3683925..3684158 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO779_RS17180 (NUITMVP1_33380) 3678786..3679664 - 879 WP_049203255.1 23S rRNA pseudouridine(2604) synthase RluF -
OO779_RS17185 (NUITMVP1_33390) 3679840..3680754 - 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
OO779_RS17190 (NUITMVP1_33400) 3680778..3681215 - 438 WP_004246810.1 D-aminoacyl-tRNA deacylase -
OO779_RS17195 (NUITMVP1_33410) 3681296..3681913 - 618 WP_004246809.1 glucose-1-phosphatase -
OO779_RS17200 (NUITMVP1_33420) 3682567..3682983 - 417 WP_049208252.1 hypothetical protein -
OO779_RS17205 (NUITMVP1_33430) 3682961..3683284 - 324 WP_049208253.1 hypothetical protein -
OO779_RS17210 (NUITMVP1_33440) 3683509..3683928 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
OO779_RS17215 (NUITMVP1_33450) 3683925..3684158 - 234 WP_012368535.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OO779_RS17220 (NUITMVP1_33460) 3684910..3686745 - 1836 WP_004246802.1 ribosome-dependent GTPase TypA -
OO779_RS17225 (NUITMVP1_33470) 3687105..3688514 + 1410 WP_004246801.1 glutamate--ammonia ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T42765 WP_012368534.1 NZ_AP026827:c3683928-3683509 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

>T42765 NZ_AP026827:c3683928-3683509 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGAGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT42765 WP_012368535.1 NZ_AP026827:c3684158-3683925 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp

>AT42765 NZ_AP026827:c3684158-3683925 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References