Detailed information of TA system TA042765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3683509..3684158
• Replicon: chromosome
• Accession: NZ_AP026827
• Organism: Proteus mirabilis strain NUITM-VP1

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: B4EZB9
• Locus tag: OO779_RS17210
• Protein ID: WP_012368534.1
• Coordinates: 3683509..3683928 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: B4EZC0
• Locus tag: OO779_RS17215
• Protein ID: WP_012368535.1
• Coordinates: 3683925..3684158 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO779_RS17180 (NUITMVP1_33380)	3678786..3679664	-	879	WP_049203255.1	23S rRNA pseudouridine(2604) synthase RluF	-
OO779_RS17185 (NUITMVP1_33390)	3679840..3680754	-	915	WP_004249085.1	fatty acid biosynthesis protein FabY	-
OO779_RS17190 (NUITMVP1_33400)	3680778..3681215	-	438	WP_004246810.1	D-aminoacyl-tRNA deacylase	-
OO779_RS17195 (NUITMVP1_33410)	3681296..3681913	-	618	WP_004246809.1	glucose-1-phosphatase	-
OO779_RS17200 (NUITMVP1_33420)	3682567..3682983	-	417	WP_049208252.1	hypothetical protein	-
OO779_RS17205 (NUITMVP1_33430)	3682961..3683284	-	324	WP_049208253.1	hypothetical protein	-
OO779_RS17210 (NUITMVP1_33440)	3683509..3683928	-	420	WP_012368534.1	type II toxin-antitoxin system VapC family toxin	Toxin
OO779_RS17215 (NUITMVP1_33450)	3683925..3684158	-	234	WP_012368535.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
OO779_RS17220 (NUITMVP1_33460)	3684910..3686745	-	1836	WP_004246802.1	ribosome-dependent GTPase TypA	-
OO779_RS17225 (NUITMVP1_33470)	3687105..3688514	+	1410	WP_004246801.1	glutamate--ammonia ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (9-56)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15371.88 Da
• Isoelectric Point: 7.7288

>T42765 WP_012368534.1 NZ_AP026827:c3683928-3683509 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Nucleotide

• Length: 420 bp

>T42765 NZ_AP026827:c3683928-3683509 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGAGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8890.06 Da
• Isoelectric Point: 4.4870

>AT42765 WP_012368535.1 NZ_AP026827:c3684158-3683925 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Nucleotide

• Length: 234 bp

>AT42765 NZ_AP026827:c3684158-3683925 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Structures

Toxin

• AlphaFold DB: B4EZB9

Antitoxin

• AlphaFold DB: B4EZC0