Detailed information of TA system TA042764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3662937..3663636
• Replicon: chromosome
• Accession: NZ_AP026827
• Organism: Proteus mirabilis strain NUITM-VP1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: OO779_RS17105
• Protein ID: WP_004249093.1
• Coordinates: 3662937..3663323 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: OO779_RS17110
• Protein ID: WP_004246828.1
• Coordinates: 3663316..3663636 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO779_RS17090 (NUITMVP1_33200)	3658956..3659537	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
OO779_RS17095 (NUITMVP1_33210)	3659788..3660693	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
OO779_RS17100 (NUITMVP1_33220)	3660703..3662775	+	2073	WP_004246830.1	glycine--tRNA ligase subunit beta	-
OO779_RS17105 (NUITMVP1_33230)	3662937..3663323	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO779_RS17110 (NUITMVP1_33240)	3663316..3663636	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
OO779_RS17115 (NUITMVP1_33250)	3663685..3664119	-	435	WP_004246827.1	hypothetical protein	-
OO779_RS17120 (NUITMVP1_33260)	3664112..3664996	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
OO779_RS17125 (NUITMVP1_33270)	3665213..3666499	-	1287	WP_049196833.1	DUF3748 domain-containing protein	-
OO779_RS17130 (NUITMVP1_33280)	3666636..3667253	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
OO779_RS17135 (NUITMVP1_33290)	3667555..3668178	+	624	WP_004246821.1	guanylate kinase	-
OO779_RS17140 (NUITMVP1_33300)	3668233..3668508	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T42764 WP_004249093.1 NZ_AP026827:3662937-3663323 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T42764 NZ_AP026827:3662937-3663323 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT42764 WP_004246828.1 NZ_AP026827:3663316-3663636 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT42764 NZ_AP026827:3663316-3663636 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97