Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1506985..1507630 | Replicon | chromosome |
| Accession | NZ_AP026827 | ||
| Organism | Proteus mirabilis strain NUITM-VP1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | B4ET86 |
| Locus tag | OO779_RS07000 | Protein ID | WP_004247035.1 |
| Coordinates | 1507445..1507630 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | B4ET85 |
| Locus tag | OO779_RS06995 | Protein ID | WP_004247034.1 |
| Coordinates | 1506985..1507398 (-) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO779_RS06965 (NUITMVP1_13270) | 1502530..1502688 | - | 159 | WP_004247025.1 | hypothetical protein | - |
| OO779_RS06970 (NUITMVP1_13280) | 1503140..1503316 | + | 177 | WP_004247793.1 | hypothetical protein | - |
| OO779_RS06975 (NUITMVP1_13290) | 1503493..1504239 | - | 747 | Protein_1339 | class I SAM-dependent methyltransferase | - |
| OO779_RS06980 (NUITMVP1_13310) | 1505090..1505668 | + | 579 | WP_004247796.1 | alpha/beta hydrolase | - |
| OO779_RS06985 | 1505781..1506023 | - | 243 | WP_228766819.1 | hypothetical protein | - |
| OO779_RS06990 (NUITMVP1_13320) | 1506248..1506889 | - | 642 | WP_065424673.1 | response regulator | - |
| OO779_RS06995 (NUITMVP1_13330) | 1506985..1507398 | - | 414 | WP_004247034.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| OO779_RS07000 (NUITMVP1_13340) | 1507445..1507630 | - | 186 | WP_004247035.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| OO779_RS07005 (NUITMVP1_13350) | 1507718..1508203 | + | 486 | WP_223231960.1 | DUF1073 domain-containing protein | - |
| OO779_RS07010 (NUITMVP1_13360) | 1508146..1508514 | + | 369 | WP_223232026.1 | DUF1073 domain-containing protein | - |
| OO779_RS07015 | 1508541..1508744 | + | 204 | Protein_1347 | hypothetical protein | - |
| OO779_RS07020 | 1508805..1508957 | + | 153 | WP_155289810.1 | hypothetical protein | - |
| OO779_RS07025 (NUITMVP1_13380) | 1509070..1509621 | - | 552 | WP_049208654.1 | PH domain-containing protein | - |
| OO779_RS07030 (NUITMVP1_13390) | 1509725..1510000 | - | 276 | WP_049208653.1 | hypothetical protein | - |
| OO779_RS07040 (NUITMVP1_13400) | 1510418..1512151 | - | 1734 | WP_012367752.1 | LPS biosynthesis-modulating metalloenzyme YejM | - |
| OO779_RS07045 (NUITMVP1_13410) | 1512175..1512402 | - | 228 | WP_004247042.1 | YejL family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1506985..1519624 | 12639 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 7049.30 Da Isoelectric Point: 10.9659
>T42762 WP_004247035.1 NZ_AP026827:c1507630-1507445 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN
Download Length: 186 bp
>T42762 NZ_AP026827:c1507630-1507445 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15251.98 Da Isoelectric Point: 4.3830
>AT42762 WP_004247034.1 NZ_AP026827:c1507398-1506985 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
Download Length: 414 bp
>AT42762 NZ_AP026827:c1507398-1506985 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|