Detailed information of TA system TA042761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 727679..728339
• Replicon: chromosome
• Accession: NZ_AP026827
• Organism: Proteus mirabilis strain NUITM-VP1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: OO779_RS03340
• Protein ID: WP_004245133.1
• Coordinates: 727679..728104 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E3RLN2
• Locus tag: OO779_RS03345
• Protein ID: WP_004245128.1
• Coordinates: 728097..728339 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO779_RS03310 (NUITMVP1_06230)	722976..723425	+	450	WP_004245139.1	transcriptional regulator NrdR	-
OO779_RS03315 (NUITMVP1_06240)	723474..724631	+	1158	WP_004245138.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
OO779_RS03320 (NUITMVP1_06250)	724844..725314	+	471	WP_004245137.1	6,7-dimethyl-8-ribityllumazine synthase	-
OO779_RS03325 (NUITMVP1_06260)	725343..725756	+	414	WP_004245136.1	transcription antitermination factor NusB	-
OO779_RS03330 (NUITMVP1_06270)	725850..726830	+	981	WP_004245135.1	thiamine-phosphate kinase	-
OO779_RS03335 (NUITMVP1_06280)	726916..727251	-	336	WP_004245134.1	zinc ribbon domain-containing protein YjdM	-
OO779_RS03340 (NUITMVP1_06290)	727679..728104	-	426	WP_004245133.1	type II toxin-antitoxin system VapC family toxin	Toxin
OO779_RS03345 (NUITMVP1_06300)	728097..728339	-	243	WP_004245128.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
OO779_RS03350 (NUITMVP1_06310)	728455..729462	-	1008	WP_012367471.1	ribose operon transcriptional repressor RbsR	-
OO779_RS03355 (NUITMVP1_06320)	729467..730393	-	927	WP_004245126.1	ribokinase	-
OO779_RS03360 (NUITMVP1_06330)	730471..731361	-	891	WP_004245125.1	ribose ABC transporter substrate-binding protein RbsB	-
OO779_RS03365 (NUITMVP1_06340)	731401..732366	-	966	WP_004245124.1	ribose ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15924.18 Da
• Isoelectric Point: 6.4879

>T42761 WP_004245133.1 NZ_AP026827:c728104-727679 [Proteus mirabilis]
MIKYLLDTNIVIFTIKRKPEFLLPKFNQHAEQLAISTITLAELIFGAEKSVNPAKNLATVNDFVSRLTVLSYDDLAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTVINSDPQTD

Nucleotide

• Length: 426 bp

>T42761 NZ_AP026827:c728104-727679 [Proteus mirabilis]
ATGATTAAATACCTATTAGATACAAATATTGTTATATTCACTATTAAACGCAAGCCTGAGTTTTTATTACCAAAATTCAA
CCAACATGCTGAACAATTAGCTATTTCTACAATTACACTCGCTGAGCTCATTTTTGGTGCTGAAAAAAGTGTAAATCCAG
CCAAAAACTTAGCTACGGTTAACGACTTTGTTTCTCGACTGACTGTTTTATCTTACGATGACTTAGCAGCTTTTCATTAT
GGAGACATTAGAGCAACACTAGAAAAACAGGGAAAACGCATTGGTGATAACGACTTACATATAGCAGCACATGCTAGAAG
TAAGGGGCTAATAGTCGTTACCAATAATACTCGAGAATTTGAAAGAGTTGATGGTTTAAGAATTGAGGATTGGACCGTTA
TTAACTCAGACCCCCAAACTGATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9390.48 Da
• Isoelectric Point: 4.6182

>AT42761 WP_004245128.1 NZ_AP026827:c728339-728097 [Proteus mirabilis]
MIQYGKVFMSNRTQNVRLPAETRFPDDVKEVFVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQATSERESFDD

Nucleotide

• Length: 243 bp

>AT42761 NZ_AP026827:c728339-728097 [Proteus mirabilis]
ATGATCCAGTATGGCAAAGTATTTATGAGCAATAGAACACAAAATGTTCGATTACCCGCTGAGACTCGATTTCCGGATGA
TGTAAAAGAAGTTTTTGTTCGCGTCAAAGGCAAAGAGAGAATAATCACACCTATACAAAATGCATGGGATAGCTTTTTCT
TATCAGAAAAGTCTGTAACAGATGATTTCTTATCTGAAAGGCCTGATCAAGCCACAAGTGAAAGAGAATCCTTTGATGAT
TAA