42760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 81740..83338 Replicon chromosome
Accession NZ_AP026827
Organism Proteus mirabilis strain NUITM-VP1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OO779_RS00420 Protein ID WP_063108770.1
Coordinates 81740..83083 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OO779_RS00425 Protein ID WP_041701484.1
Coordinates 83087..83338 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO779_RS00400 (NUITMVP1_00780) 77357..78541 + 1185 WP_004246423.1 multidrug efflux MFS transporter EmrD -
OO779_RS00405 (NUITMVP1_00790) 78651..80183 - 1533 WP_004246422.1 glycerol kinase GlpK -
OO779_RS00410 (NUITMVP1_00800) 80226..81041 - 816 WP_004246421.1 MIP/aquaporin family protein -
OO779_RS00415 (NUITMVP1_00810) 81338..81580 + 243 WP_012368679.1 cell division protein ZapB -
OO779_RS00420 (NUITMVP1_00820) 81740..83083 - 1344 WP_063108770.1 type II toxin-antitoxin system HipA family toxin Toxin
OO779_RS00425 (NUITMVP1_00830) 83087..83338 - 252 WP_041701484.1 helix-turn-helix domain-containing protein Antitoxin
OO779_RS00430 83579..83844 + 266 Protein_85 IS4 family transposase -
OO779_RS00435 (NUITMVP1_00840) 83914..84432 - 519 WP_004246419.1 ribonuclease E activity regulator RraA -
OO779_RS00440 (NUITMVP1_00850) 84541..85458 - 918 WP_175216705.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
OO779_RS00445 (NUITMVP1_00860) 85557..86897 - 1341 WP_004246417.1 HslU--HslV peptidase ATPase subunit -
OO779_RS00450 (NUITMVP1_00870) 86910..87440 - 531 WP_004246416.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49787.20 Da        Isoelectric Point: 5.3203

>T42760 WP_063108770.1 NZ_AP026827:c83083-81740 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN

Download         Length: 1344 bp

>T42760 NZ_AP026827:c83083-81740 [Proteus mirabilis]
ATGAAAGCTCAAATACTATCTGTTGCTATGAATGGTGATTTGGTTGGTAAACTAACCAAAAATACTGATGGTGGGATGTC
ATTTCAATACGCAGAAGAATGGTTGGCTGAACCAGGAGCGCGGGCAATCTCATTATCACTTCCTTTGCAAAAGGGGCGCA
TAATCGGTAGCGCAGTTTACAATTTCTTCAGCAACCTTTTACCTGATTCTGAGGCAATTATTGATAGAATGCAGATTCGT
TTTAAGGTAAAAACAAACCATCCTTTTGATCTGCTAGCCGCTGTAGGTCGTGACTGTGTTGGCGCAATCCAATTATATTC
TCCTGATACTGAAATTCCATCGGTGATGGAAACCCATGCTGAACCTTTAAATGAAAATCAAATCGAAGAGCTTTTAGACG
GTTATCAAACCGCCCCCCTTGGAATGTCCGAGGATGTAGACTTTCGGATCTCCCTTGCAGGGGCTCAAGAGAAAACAGCA
TTACTTTGGTATCAAGACTGTTGGCAGCGACCACAAGGCAGTACCCCGACAAGTCATATTTTCAAATTGCCCATAGGTCT
GATTGAACACCATAATATTGATCTGCGCGAAAGCTGTGAAAACGAATGGCTATGCTTGTGTATAGCAAGAGAATTTGGAT
TTCCAGTCACCAACGCTGAATTGGCAATATTCGGTCAGAAAAAGGTACTGATCGTAGAGCGTTTTGACCGAAAATGGTCC
TCATCTGGGAACTGGCTGTTGCGCCTTCCCCAAGAGGATTGCTGTCAGGCTTTGAGCGTTGCCCCTGCATTAAAATATGA
ATCTGATGGTGGTCCAGGTATTGAATCTATCATGACGTTGCTTTTGGGCTCACAAAAAGCCATCGACGATAGAGAAATGT
TTTTTAAATCACAAATTCTGTTCTGGATGCTGGCCGCTATAGATGGGCATGGGAAAAACTTTTCCATCTTCATTGAATCT
GGAACATCTTTTCGTTTAACGCCCTTGTATGATGTTATGTCTGCTTTCCCAATTTTTGAAGCACGAGGAATTGAGATAAA
AAAGGCCAAAATGGCTATGGCATTACAAGGAAAAAACAGACAATACAATTTTTCCATGATACAACCTCGTCATTTTATCT
CTACCGCTACAAAGGTCGGGTTTCCAACAAAAACCGCAATGGAGCTAATGGTTGATATGGCCGAAAAGACTGATGCAGTT
ATAGCTACCGTATCATCTCAACTACCTGCGGACTTTCCTGAGCATATCAGTAACGCCATATTTAGTGGGTTATCAATACA
AGCCGATAAGATTAAAAGATGGTCTTCAGGAACGAGCTCACAAAATATGATGGTTTCGAATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.83 Da        Isoelectric Point: 9.8955

>AT42760 WP_041701484.1 NZ_AP026827:c83338-83087 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Download         Length: 252 bp

>AT42760 NZ_AP026827:c83338-83087 [Proteus mirabilis]
ATGAAAATTACAACGCCATCAATGTTAGCCGCTGCAATACATGACTTGCGCAAACAAAGTAAATTAACCCAAGCTCAAAC
GGCTGAACAAGTCGGTCTCAGGCAAGCAACTGTCTCTGAATTTGAGAACAACCCAGAATCAACAAAACTCGAAACGCTTT
TCAAAATCCTTGCCTCTTTGGAACTGGAACTACATGTAGTGAAGCGAGGAAAAAACCTGAGTGAGGGTAAGGTTTGGAAT
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References