Detailed information of TA system TA042759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 14598..15199
• Replicon: chromosome
• Accession: NZ_AP026827
• Organism: Proteus mirabilis strain NUITM-VP1

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: OO779_RS00065
• Protein ID: WP_049196622.1
• Coordinates: 14598..14981 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: OO779_RS00070
• Protein ID: WP_004246496.1
• Coordinates: 14978..15199 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO779_RS00040 (NUITMVP1_00080)	9969..10427	+	459	WP_004249766.1	GNAT family N-acetyltransferase	-
OO779_RS00045 (NUITMVP1_00090)	10523..11260	-	738	WP_004249950.1	tetratricopeptide repeat protein	-
OO779_RS00050 (NUITMVP1_00100)	11369..12268	+	900	WP_185166141.1	N-acetylmuramic acid 6-phosphate etherase	-
OO779_RS00055 (NUITMVP1_00110)	12625..13614	-	990	WP_261212385.1	HipA domain-containing protein	-
OO779_RS00060 (NUITMVP1_00120)	13876..14190	-	315	WP_004246498.1	helix-turn-helix transcriptional regulator	-
OO779_RS00065 (NUITMVP1_00130)	14598..14981	-	384	WP_049196622.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
OO779_RS00070 (NUITMVP1_00140)	14978..15199	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OO779_RS00075 (NUITMVP1_00150)	15421..16284	-	864	WP_004249947.1	YicC/YloC family endoribonuclease	-
OO779_RS00080 (NUITMVP1_00160)	16411..17127	+	717	WP_004249760.1	ribonuclease PH	-
OO779_RS00085 (NUITMVP1_00170)	17209..17853	+	645	WP_004246493.1	orotate phosphoribosyltransferase	-
OO779_RS00090 (NUITMVP1_00180)	18172..18777	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
OO779_RS00095 (NUITMVP1_00190)	18897..19355	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14529.57 Da
• Isoelectric Point: 7.4005

>T42759 WP_049196622.1 NZ_AP026827:c14981-14598 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T42759 NZ_AP026827:c14981-14598 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATATGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT42759 WP_004246496.1 NZ_AP026827:c15199-14978 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT42759 NZ_AP026827:c15199-14978 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9