Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 7031..7532 | Replicon | plasmid pIPCEC48_2 |
| Accession | NZ_AP026796 | ||
| Organism | Escherichia coli strain IPCEC48 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | OPA53_RS26460 | Protein ID | WP_000702247.1 |
| Coordinates | 7031..7291 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | OPA53_RS26465 | Protein ID | WP_001132407.1 |
| Coordinates | 7281..7532 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OPA53_RS26415 (IPCEC48_50690) | 2570..2722 | + | 153 | Protein_2 | FlmC family protein | - |
| OPA53_RS26420 | 2670..2789 | + | 120 | WP_228932012.1 | Hok/Gef family protein | - |
| OPA53_RS26425 (IPCEC48_50700) | 2939..3535 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| OPA53_RS26430 (IPCEC48_50710) | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| OPA53_RS26435 (IPCEC48_50720) | 3911..4576 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| OPA53_RS26440 (IPCEC48_50730) | 5174..5503 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| OPA53_RS26445 (IPCEC48_50740) | 6084..6407 | + | 324 | WP_072834379.1 | hypothetical protein | - |
| OPA53_RS26450 (IPCEC48_50750) | 6449..6658 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| OPA53_RS26455 (IPCEC48_50760) | 6755..6979 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| OPA53_RS26460 (IPCEC48_50770) | 7031..7291 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| OPA53_RS26465 (IPCEC48_50780) | 7281..7532 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| OPA53_RS26470 (IPCEC48_50790) | 8082..8360 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| OPA53_RS26475 (IPCEC48_50810) | 8780..9046 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| OPA53_RS26480 (IPCEC48_50820) | 9153..9596 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| OPA53_RS26485 (IPCEC48_50830) | 9893..10075 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| OPA53_RS26490 (IPCEC48_50840) | 10100..10537 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| OPA53_RS26495 (IPCEC48_50850) | 10668..10994 | - | 327 | WP_000206697.1 | hypothetical protein | - |
| OPA53_RS26500 (IPCEC48_50860) | 11014..11721 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| OPA53_RS26505 (IPCEC48_50870) | 11723..12475 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60947 | 60947 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T42757 WP_000702247.1 NZ_AP026796:7031-7291 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T42757 NZ_AP026796:7031-7291 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT42757 WP_001132407.1 NZ_AP026796:7281-7532 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT42757 NZ_AP026796:7281-7532 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|