Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1949622..1950453 Replicon chromosome
Accession NZ_AP026788
Organism Escherichia coli strain IPCEC42

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag OPA56_RS09260 Protein ID WP_000854815.1
Coordinates 1949622..1949996 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag OPA56_RS09265 Protein ID WP_001280918.1
Coordinates 1950085..1950453 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPA56_RS09225 (1945018) 1945018..1946184 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
OPA56_RS09230 (1946303) 1946303..1946776 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
OPA56_RS09235 (1946974) 1946974..1948032 + 1059 WP_001200889.1 FUSC family protein -
OPA56_RS09240 (1948204) 1948204..1948533 + 330 WP_000450409.1 DUF496 family protein -
OPA56_RS09245 (1948634) 1948634..1948990 - 357 WP_023142355.1 EutP/PduV family microcompartment system protein -
OPA56_RS09250 (1949305) 1949305..1949385 - 81 Protein_1813 hypothetical protein -
OPA56_RS09255 (1949431) 1949431..1949625 - 195 WP_000988600.1 DUF5983 family protein -
OPA56_RS09260 (1949622) 1949622..1949996 - 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
OPA56_RS09265 (1950085) 1950085..1950453 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OPA56_RS09270 (1950469) 1950469..1951113 - 645 WP_000086752.1 hypothetical protein -
OPA56_RS09275 (1951132) 1951132..1951353 - 222 WP_000692345.1 DUF987 domain-containing protein -
OPA56_RS09280 (1951416) 1951416..1951892 - 477 WP_001186200.1 RadC family protein -
OPA56_RS09285 (1951908) 1951908..1952381 - 474 WP_001542276.1 antirestriction protein -
OPA56_RS09290 (1952475) 1952475..1952720 - 246 WP_001164966.1 hypothetical protein -
OPA56_RS09295 (1952720) 1952720..1953538 - 819 WP_001542275.1 DUF932 domain-containing protein -
OPA56_RS09300 (1953759) 1953759..1954169 - 411 WP_000846703.1 hypothetical protein -
OPA56_RS09305 (1954185) 1954185..1954535 - 351 Protein_1824 hypothetical protein -
OPA56_RS09310 (1954618) 1954618..1955364 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T42692 WP_000854815.1 NZ_AP026788:c1949996-1949622 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T42692 NZ_AP026788:c1949996-1949622 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT42692 WP_001280918.1 NZ_AP026788:c1950453-1950085 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT42692 NZ_AP026788:c1950453-1950085 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References