Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1004210..1004864 Replicon chromosome
Accession NZ_AP026788
Organism Escherichia coli strain IPCEC42

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag OPA56_RS05010 Protein ID WP_000244765.1
Coordinates 1004457..1004864 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag OPA56_RS05005 Protein ID WP_000354050.1
Coordinates 1004210..1004476 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPA56_RS04985 (1000298) 1000298..1001731 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
OPA56_RS04990 (1001776) 1001776..1002087 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
OPA56_RS04995 (1002251) 1002251..1002910 + 660 WP_000250275.1 hemolysin III family protein -
OPA56_RS05000 (1002987) 1002987..1003967 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
OPA56_RS05005 (1004210) 1004210..1004476 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
OPA56_RS05010 (1004457) 1004457..1004864 + 408 WP_000244765.1 protein YgfX Toxin
OPA56_RS05015 (1004904) 1004904..1005425 - 522 WP_001055874.1 flavodoxin FldB -
OPA56_RS05020 (1005537) 1005537..1006433 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
OPA56_RS05025 (1006458) 1006458..1007168 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OPA56_RS05030 (1007174) 1007174..1008907 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T42690 WP_000244765.1 NZ_AP026788:1004457-1004864 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T42690 NZ_AP026788:1004457-1004864 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT42690 WP_000354050.1 NZ_AP026788:1004210-1004476 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT42690 NZ_AP026788:1004210-1004476 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References