Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1335417..1336042 Replicon chromosome
Accession NZ_AP026783
Organism Escherichia coli strain IPCEC31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OO978_RS06525 Protein ID WP_000911330.1
Coordinates 1335644..1336042 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag OO978_RS06520 Protein ID WP_000450524.1
Coordinates 1335417..1335644 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO978_RS06495 (1331220) 1331220..1331690 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
OO978_RS06500 (1331690) 1331690..1332262 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
OO978_RS06505 (1332408) 1332408..1333286 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
OO978_RS06510 (1333303) 1333303..1334337 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
OO978_RS06515 (1334550) 1334550..1335263 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
OO978_RS06520 (1335417) 1335417..1335644 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
OO978_RS06525 (1335644) 1335644..1336042 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
OO978_RS06530 (1336189) 1336189..1337052 + 864 WP_001267507.1 neutral zinc metallopeptidase -
OO978_RS06535 (1337067) 1337067..1339082 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
OO978_RS06540 (1339156) 1339156..1339854 + 699 WP_000679823.1 esterase -
OO978_RS06545 (1339964) 1339964..1340164 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T42664 WP_000911330.1 NZ_AP026783:1335644-1336042 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T42664 NZ_AP026783:1335644-1336042 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT42664 WP_000450524.1 NZ_AP026783:1335417-1335644 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT42664 NZ_AP026783:1335417-1335644 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References